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Cytokine profiles in asthma families depend on age and phenotype

Pukelsheim, K and Stoeger, T and Kutschke, D and Ganguly, K and Wjst, M (2010) Cytokine profiles in asthma families depend on age and phenotype. PLoS ONE, 5 (12).

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Abstract

Background: Circulating cytokine patterns may be relevant for the diagnosis of asthma, for the discrimination of certain phenotypes, and prognostic factors for exacerbation of disease. Methodology/Principal Findings: In this study we investigated serum samples from 944 individuals of 218 asthma-affected families by a multiplex, microsphere based system detecting at high sensitivity eleven asthma associated mediators: eotaxin (CCL11), granulocyte macrophage stimulating factor (GM-CSF), interferon gamma (IFNγ), interleukin-4 (IL-4), IL-5, IL-8, IL-10, IL-12 (p40), IL-13, IL-17 and tumor necrosis factor alpha (TNFα). Single cytokine levels were largely similar between asthmatic and healthy individuals when analysing asthma as single disease entity. Regulatory differences between parental and pediatric asthma were reflected by six of the eleven mediators analyzed (eotaxin, IL-4, IL-5, IL-10, IL-12, TNFα). IL-12 (p40) and IL-5 were the best predictor for extrinsic asthma in children with an increased odds ratio of 2.85 and 1.96 per log pg/ml increase (IL-12 (p40): 1.2-6.8, p = 0.019, and IL-5: 1.2-2.5, p = 0.025). Frequent asthma attacks in children are associated with elevated IL-5 serum levels (p = 0.013). Cytokine patterns seem to be individually balanced in both, healthy and diseased adults and children, with various cytokines correlating among each other (IL-17 and IFNγ (rs = 0.67), IL-4 and IL-5 (rs = 0.55), IFNγ and GM-CSF (rs = 0.54)). Conclusion/Significance: Our data support mainly an age- but also an asthma phenotype-dependent systemic immune regulation. © 2010 Pukelsheim et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pukelsheim, K
Stoeger, T
Kutschke, D
Ganguly, Kkog8@pitt.eduKOG8
Wjst, M
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorCheckley, WilliamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 December 2010
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 5
Number: 12
DOI or Unique Handle: 10.1371/journal.pone.0014299
Schools and Programs: Graduate School of Public Health > Environmental and Occupational Health
Refereed: Yes
MeSH Headings: Adolescent; Adult; Age Factors; Asthma--genetics; Asthma--metabolism; Case-Control Studies; Child; Child, Preschool; Cytokines--metabolism; Family Health; Female; Humans; Interleukin-12--metabolism; Male; Middle Aged; Odds Ratio; Phenotype; Prognosis; ROC Curve
Other ID: NLM PMC3001464
PubMed Central ID: PMC3001464
PubMed ID: 21179211
Date Deposited: 25 Aug 2012 16:44
Last Modified: 19 Jun 2021 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/13664

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