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Endothelin-1 gene expression in human pheochromocytoma.

Amico, JA and Clarke, MR and Watson, CG and Kim, NB and Bononi, PL and Crowley, Rebecca S and Horwitz, MJ (1993) Endothelin-1 gene expression in human pheochromocytoma. The Journal of laboratory and clinical medicine, 122 (6). 667 - 672. ISSN 0022-2143

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We examined expression of human endothelin-1 (ET-1) in adrenal tissues removed from five patients with pheochromocytomas and two patients with aldosterone-producing adenomas. The pheochromocytomas contained a 2.3 kilobase ET-1 transcript, which was not found int he aldosteronomas. Constitutive expression of ET-1 varied in magnitude among the pheochromocytomas but was generally at a low level. Immunohistochemical staining of the pheochromocytomas with an antiserum to human ET-1 showed the presence of immunoreactive ET-1 as well. The presence of ET-1 messenger ribonucleic acid and ET-1 immunoreactivity in human pheochromocytomas suggests a possible paracrine role for this peptide in human chromaffin cells.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Amico, JA
Clarke, MR
Watson, CG
Kim, NB
Bononi, PL
Crowley, Rebecca S
Horwitz, MJ
Date: December 1993
Date Type: Publication
Journal or Publication Title: The Journal of laboratory and clinical medicine
Volume: 122
Number: 6
Publisher: Elsevier / Central Society for Clinical Research
Page Range: 667 - 672
Schools and Programs: School of Medicine > Biomedical Informatics
Refereed: Yes
ISSN: 0022-2143
MeSH Headings: Adenoma--metabolism; Adrenal Gland Neoplasms--metabolism; Adrenal Glands--metabolism; Adult; Aged; Endothelins--genetics; Endothelium, Vascular--metabolism; Epinephrine--metabolism; Female; Gene Expression; Humans; Immunoenzyme Techniques; Male; Middle Aged; Norepinephrine--metabolism; Pheochromocytoma--metabolism; RNA--metabolism; Umbilical Veins
PubMed ID: 7504041
Date Deposited: 29 Aug 2012 15:59
Last Modified: 01 Nov 2017 14:03


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