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Detrimental effects of environmental tobacco smoke in relation to asthma severity

Comhair, SAA and Gaston, BM and Ricci, KS and Hammel, J and Dweik, RA and Teague, WG and Meyers, D and Ampleford, EJ and Bleecker, ER and Busse, WW and Calhoun, WJ and Castro, M and Chung, KF and Curran-Everett, D and Israel, E and Jarjour, WN and Moore, W and Peters, SP and Wenzel, S and Hazen, SL and Erzurum, SC (2011) Detrimental effects of environmental tobacco smoke in relation to asthma severity. PLoS ONE, 6 (5).

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Abstract

Background: Environmental tobacco smoke (ETS) has adverse effects on the health of asthmatics, however the harmful consequences of ETS in relation to asthma severity are unknown. Methods: In a multicenter study of severe asthma, we assessed the impact of ETS exposure on morbidity, health care utilization and lung functions; and activity of systemic superoxide dismutase (SOD), a potential oxidative target of ETS that is negatively associated with asthma severity. Findings: From 2002-2006, 654 asthmatics (non-severe 366, severe 288) were enrolled, among whom 109 non-severe and 67 severe asthmatics were routinely exposed to ETS as ascertained by history and validated by urine cotinine levels. ETS-exposure was associated with lower quality of life scores; greater rescue inhaler use; lower lung function; greater bronchodilator responsiveness; and greater risk for emergency room visits, hospitalization and intensive care unit admission. ETS-exposure was associated with lower levels of serum SOD activity, particularly in asthmatic women of African heritage. Interpretation: ETS-exposure of asthmatic individuals is associated with worse lung function, higher acuity of exacerbations, more health care utilization, and greater bronchial hyperreactivity. The association of diminished systemic SOD activity to ETS exposure provides for the first time a specific oxidant mechanism by which ETS may adversely affect patients with asthma. © 2011 Comhair et al.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Comhair, SAA
Gaston, BM
Ricci, KS
Hammel, J
Dweik, RA
Teague, WG
Meyers, D
Ampleford, EJ
Bleecker, ER
Busse, WW
Calhoun, WJ
Castro, M
Chung, KF
Curran-Everett, D
Israel, E
Jarjour, WN
Moore, W
Peters, SP
Wenzel, S
Hazen, SL
Erzurum, SC
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
InvestigatorIsrael, ElliotUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorLevy, Bruce DUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMarigowda, GauthamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorClinic, ClevelandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSerpil, AmericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorErzurum, CUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorDweik, Raed AUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorComhair, Suzy A AUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBaaklini, MarcelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorLaskowski, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMattox, EmmeaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorFitzpatrick, Anne MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorWhitlock, DeniseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorChung, Kian FanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorHew, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMeah, SallyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorHew, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMacedo, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorChow, FlorenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorWenzel, Sally EUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorHolguin, FernandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorChamberlin, JenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCalhoun, William JUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorAmeredes, Bill TUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorGerald Teague, WUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorThompson-Batt, DeniseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBusse, William WUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorJarjour, NizarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSorkness, RonaldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorFain, SeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBillmeyer, ErinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSwenson, CheriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorCrisafi, GinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorFrisque, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorKolk, DanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBleecker, Eugene RUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMeyers, DeborahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorMoore, WendyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorPeters, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorPascual, RodolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorHastie, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorHawkins, GregoryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorKrings, JeffreyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSmith, ReginaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorLouis, StUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorBacharier, LeonardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorTarsi, JaimeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorKnowles, RuthieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorRobinson, MauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSilveira, LoriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorDiseases, LungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorNoel, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
InvestigatorSmith, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 13 May 2011
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 6
Number: 5
DOI or Unique Handle: 10.1371/journal.pone.0018574
Refereed: Yes
MeSH Headings: Adolescent; Adult; Aged; Asthma--blood; Asthma--chemically induced; Asthma--physiopathology; Child; Environmental Exposure--adverse effects; Female; Humans; Male; Middle Aged; Respiratory Function Tests; Superoxide Dismutase--blood; Tobacco Smoke Pollution--adverse effects; Young Adult
Other ID: NLM PMC3087715
PubMed Central ID: PMC3087715
PubMed ID: 21572527
Date Deposited: 29 Aug 2012 21:12
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/13830

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