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Scedosporium apiospermum (Pseudallescheria boydii) infection in a heart transplant recipient: a case of mistaken identity.

Lopez, FA and Crowley, Rebecca S and Wastila, L and Valantine, HA and Remington, JS (1998) Scedosporium apiospermum (Pseudallescheria boydii) infection in a heart transplant recipient: a case of mistaken identity. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 17 (3). 321 - 324. ISSN 1053-2498

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Abstract

We report a case of fatal central nervous system infection with Scedosporium apiospermum (Pseudallescheria boydii) in a heart transplant recipient. This ubiquitous fungus is known to cause mycetoma and localized infections in patients with otherwise normal conditions. Disseminated infections occur rarely and are seen primarily in patients who are receiving immunosuppressive medications or who have neutropenia. Often life-threatening when infection is disseminated and involves the central nervous system, this diagnosis is difficult to make rapidly because S. apiospermum (P. boydii) mimics Aspergillus spp. and Fusarium spp., both clinically and histopathologically. Imidazoles such as miconazole, but not amphotericin B, are considered the therapeutic compounds of choice. Improved diagnostic and treatment options are needed to optimize management of infections with S. apiospermum (P. boydii).

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lopez, FA
Crowley, Rebecca S
Wastila, L
Valantine, HA
Remington, JS
Date: March 1998
Date Type: Publication
Journal or Publication Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Volume: 17
Number: 3
Page Range: 321 - 324
Schools and Programs: School of Medicine > Biomedical Informatics
Refereed: Yes
ISSN: 1053-2498
Article Type: Research Article
MeSH Headings: Adult; Brain Diseases--microbiology; Central Nervous System Diseases--microbiology; Fatal Outcome; Heart Transplantation; Humans; Male; Mycetoma--diagnosis; Mycetoma--microbiology; Postoperative Complications; Pseudallescheria--isolation & purification
PubMed ID: 9563611
Date Deposited: 29 Aug 2012 21:02
Last Modified: 01 Nov 2017 14:03
URI: http://d-scholarship.pitt.edu/id/eprint/13835

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