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Cumulative inflammatory load is associated with short leukocyte telomere length in the health, aging and body composition study

O'Donovan, A and Pantell, MS and Puterman, E and Dhabhar, FS and Blackburn, EH and Yaffe, K and Cawthon, RM and Opresko, PL and Hsueh, WC and Satterfield, S and Newman, AB and Ayonayon, HN and Rubin, SM and Harris, TB and Epel, ES (2011) Cumulative inflammatory load is associated with short leukocyte telomere length in the health, aging and body composition study. PLoS ONE, 6 (5).

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Abstract

Background: Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells with critically short telomeres produce pro-inflammatory factors. However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction. Methodology/Principal Findings: To address this issue, we examined if individuals with high levels of the systemic inflammatory markers interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) had increased odds for short LTL. Our sample included 1,962 high-functioning adults who participated in the Health, Aging and Body Composition Study (age range: 70-79 years). Logistic regression analyses indicated that individuals with high levels of either IL-6 or TNF-α had significantly higher odds for short LTL. Furthermore, individuals with high levels of both IL-6 and TNF-α had significantly higher odds for short LTL compared with those who had neither high (OR = 0.52, CI = 0.37-0.72), only IL-6 high (OR = 0.57, CI = 0.39-0.83) or only TNF-α high (OR = 0.67, CI = 0.46-0.99), adjusting for a wide variety of established risk factors and potential confounds. In contrast, CRP was not associated with LTL. Conclusions/Significance: Results suggest that cumulative inflammatory load, as indexed by the combination of high levels of IL-6 and TNF-α, is associated with increased odds for short LTL. In contrast, high levels of CRP were not accompanied by short LTL in this cohort of older adults. These data provide the first large-scale demonstration of links between inflammatory markers and LTL in an older population.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
O'Donovan, A
Pantell, MS
Puterman, E
Dhabhar, FS
Blackburn, EH
Yaffe, K
Cawthon, RM
Opresko, PLplo4@pitt.eduPLO4
Hsueh, WC
Satterfield, S
Newman, ABANEWMAN@pitt.eduANEWMAN
Ayonayon, HN
Rubin, SM
Harris, TB
Epel, ES
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorLichterfeld, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 18 May 2011
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 6
Number: 5
DOI or Unique Handle: 10.1371/journal.pone.0019687
Schools and Programs: Graduate School of Public Health > Environmental and Occupational Health
Refereed: Yes
MeSH Headings: Aged; Aging; Biological Markers; C-Reactive Protein; Humans; Inflammation--pathology; Interleukin-6--analysis; Leukocytes--ultrastructure; Odds Ratio; Telomere--ultrastructure; Tumor Necrosis Factor-alpha--analysis
Other ID: NLM PMC3094351
PubMed Central ID: PMC3094351
PubMed ID: 21602933
Date Deposited: 29 Aug 2012 21:09
Last Modified: 22 May 2019 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/13856

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