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Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque

Zinman, G and Brower-Sinning, R and Emeche, CH and Ernst, J and Huang, GTW and Mahony, S and Myers, AJ and O'Dee, DM and Flynn, JAL and Nau, GJ and Ross, TM and Salter, RD and Benos, PV and Bar Joseph, Z and Morel, PA (2011) Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque. PLoS ONE, 6 (7).

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Abstract

Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. To determine the similarities and differences between the responses of mice and macaques to invading pathogens we profiled alveolar macrophages from these species following infection with two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were collected at 6 time points following each infection and expression profiles were compared across and between species. Our analyses identified a core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway. In addition, we identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens. On the other hand we also found several species and pathogen specific response patterns. These results provide new insights into mechanisms by which the innate immune system responds to, and interacts with, invading pathogens. © 2011 Zinman et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zinman, G
Brower-Sinning, R
Emeche, CH
Ernst, J
Huang, GTW
Mahony, S
Myers, AJ
O'Dee, DM
Flynn, JAL
Nau, GJgjnau@pitt.eduGJNAU
Ross, TM
Salter, RD
Benos, PVbenos@pitt.eduBENOS
Bar Joseph, Z
Morel, PAmorel@pitt.eduMOREL
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorSchonbach, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 26 July 2011
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 6
Number: 7
DOI or Unique Handle: 10.1371/journal.pone.0022401
Schools and Programs: School of Medicine > Computational Biology
School of Medicine > Immunology
School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
MeSH Headings: Animals; Bacteria--immunology; Francisella tularensis--immunology; Gene Expression Profiling; Gene Expression Regulation; Host-Pathogen Interactions--genetics; Host-Pathogen Interactions--immunology; Immunity, Innate--genetics; Immunity, Innate--immunology; Influenza A virus--immunology; Interferon Regulatory Factor-7--genetics; Interferon Regulatory Factor-7--metabolism; Macaca--microbiology; Macaca--virology; Macrophages, Alveolar--metabolism; Macrophages, Alveolar--microbiology; Macrophages, Alveolar--virology; Mice; Mycobacterium tuberculosis--immunology; Oligonucleotide Array Sequence Analysis; Orthomyxoviridae Infections--genetics; Orthomyxoviridae Infections--virology; Signal Transduction--genetics; Species Specificity; Tuberculosis--genetics; Tuberculosis--microbiology; Tularemia--genetics; Tularemia--microbiology; Up-Regulation; Viruses--immunology
Other ID: NLM PMC3138787
PubMed Central ID: PMC3138787
PubMed ID: 21789257
Date Deposited: 05 Sep 2012 17:50
Last Modified: 13 Oct 2017 22:55
URI: http://d-scholarship.pitt.edu/id/eprint/13877

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