Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Genome-wide association study identifies four loci associated with eruption of permanent teeth

Geller, F and Feenstra, B and Zhang, H and Shaffer, JR and Hansen, T and Esserlind, AL and Boyd, HA and Nohr, EA and Timpson, NJ and Fatemifar, G and Paternoster, L and Evans, DM and Weyant, RJ and Levy, SM and Lathrop, M and Da Smith, G and Murray, JC and Olesen, J and Werge, T and Marazita, ML and Sørensen, TIA and Melbye, M (2011) Genome-wide association study identifies four loci associated with eruption of permanent teeth. PLoS Genetics, 7 (9). ISSN 1553-7390

Published Version
Available under License : See the attached license file.

Download (284kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P<5×10-8 and were replicated in four independent study groups from the United States and Denmark with a total of 3,762 individuals; all combined P-values were below 10-11. Two loci agreed with previous findings in primary tooth eruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles. © 2011 Geller et al.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Geller, F
Feenstra, B
Zhang, H
Shaffer, JRjohn.r.shaffer@pitt.eduJRS51
Hansen, T
Esserlind, AL
Boyd, HA
Nohr, EA
Timpson, NJ
Fatemifar, G
Paternoster, L
Evans, DM
Weyant, RJrjw1@pitt.eduRJW10000-0002-5252-9120
Levy, SM
Lathrop, M
Da Smith, G
Murray, JC
Olesen, J
Werge, T
Marazita, MLmarazita@pitt.eduMARAZITA
Sørensen, TIA
Melbye, M
ContributionContributors NameEmailPitt UsernameORCID
Date: 1 September 2011
Date Type: Publication
Journal or Publication Title: PLoS Genetics
Volume: 7
Number: 9
DOI or Unique Handle: 10.1371/journal.pgen.1002275
Schools and Programs: School of Public Health > Human Genetics
School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 1553-7390
MeSH Headings: Adolescent; Alleles; Child; Cohort Studies; Denmark; Female; Genome-Wide Association Study; Genotype; HMGA2 Protein--genetics; Humans; Male; Membrane Proteins--genetics; Polymorphism, Single Nucleotide--genetics; Tooth Eruption--genetics; Tooth, Deciduous--physiology; United States
Other ID: NLM PMC3169538
PubMed Central ID: PMC3169538
PubMed ID: 21931568
Date Deposited: 05 Sep 2012 19:48
Last Modified: 22 Jun 2021 11:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item