Identification, replication, and fine-mapping of loci associated with adult height in individuals of African ancestry

N'Diaye, A and Chen, GK and Palmer, CD and Ge, B and Tayo, B and Mathias, RA and Ding, J and Nalls, MA and Adeyemo, A and Adoue, V and Ambrosone, CB and Atwood, L and Bandera, EV and Becker, LC and Berndt, SI and Bernstein, L and Blot, WJ and Boerwinkle, E and Britton, A and Casey, G and Chanock, SJ and Demerath, E and Deming, SL and Diver, WR and Fox, C and Harris, TB and Hernandez, DG and Hu, JJ and Ingles, SA and John, EM and Johnson, C and Keating, B and Kittles, RA and Kolonel, LN and Kritchevsky, SB and Marchand, L and Lohman, K and Liu, J and Millikan, RC and Murphy, A and Musani, S and Neslund-Dudas, C and North, KE and Nyante, S and Ogunniyi, A and Ostrander, EA and Papanicolaou, G and Patel, S and Pettaway, CA and Press, MF and Redline, S and Rodriguez-Gil, JL and Rotimi, C and Rybicki, BA and Salako, B and Schreiner, PJ and Signorello, LB and Singleton, AB and Stanford, JL and Stram, AH and Stram, DO and Strom, SS and Suktitipat, B and Thun, MJ and Witte, JS and Yanek, LR and Ziegler, RG and Zheng, W and Zhu, X and Zmuda, JM and Zonderman, AB and Evans, MK and Liu, Y and Becker, DM and Cooper, RS and Pastinen, T and Henderson, BE and Hirschhorn, JN and Lettre, G and Haiman, CA (2011) Identification, replication, and fine-mapping of loci associated with adult height in individuals of African ancestry. PLoS Genetics, 7 (10). ISSN 1553-7390

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Abstract

Adult height is a classic polygenic trait of high heritability (h 2 ~0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ~10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10 -12 and 2p14-rs4315565, P = 1.2×10 -8). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10 -4 for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits. © 2011 N'Diaye et al.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID N'Diaye, A Chen, GK Palmer, CD Ge, B Tayo, B Mathias, RA Ding, J Nalls, MA Adeyemo, A Adoue, V Ambrosone, CB Atwood, L Bandera, EV Becker, LC Berndt, SI Bernstein, L Blot, WJ Boerwinkle, E Britton, A Casey, G Chanock, SJ Demerath, E Deming, SL Diver, WR Fox, C Harris, TB Hernandez, DG Hu, JJ Ingles, SA John, EM Johnson, C Keating, B Kittles, RA Kolonel, LN Kritchevsky, SB Marchand, L Lohman, K Liu, J Millikan, RC Murphy, A Musani, S Neslund-Dudas, C North, KE Nyante, S Ogunniyi, A Ostrander, EA Papanicolaou, G Patel, S Pettaway, CA Press, MF Redline, S Rodriguez-Gil, JL Rotimi, C Rybicki, BA Salako, B Schreiner, PJ Signorello, LB Singleton, AB Stanford, JL Stram, AH Stram, DO Strom, SS Suktitipat, B Thun, MJ Witte, JS Yanek, LR Ziegler, RG Zheng, W Zhu, X Zmuda, JM ZmudaJ@edc.pitt.edu EPIDJMZ Zonderman, AB Evans, MK Liu, Y Becker, DM Cooper, RS Pastinen, T Henderson, BE Hirschhorn, JN Lettre, G Haiman, CA
Contributors:	Contribution Contributors Name Email Pitt Username ORCID Editor Visscher, Peter M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
Date:	1 October 2011
Date Type:	Publication
Journal or Publication Title:	PLoS Genetics
Volume:	7
Number:	10
DOI or Unique Handle:	10.1371/journal.pgen.1002298
Schools and Programs:	School of Public Health > Epidemiology
Refereed:	Yes
ISSN:	1553-7390
MeSH Headings:	Adult; African Americans--genetics; Aged; Aged, 80 and over; Body Height--genetics; Chromosome Mapping; European Continental Ancestry Group--genetics; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide
Other ID:	NLM PMC3188544
PubMed Central ID:	PMC3188544
PubMed ID:	21998595
Date Deposited:	10 Sep 2012 14:21
Last Modified:	22 Jun 2021 15:55
URI:	http://d-scholarship.pitt.edu/id/eprint/13980

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