Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

The expression and function of fatty acid transport protein-2 and -4 in the murine placenta

Mishima, T and Miner, JH and Morizane, M and Stahl, A and Sadovsky, Y (2011) The expression and function of fatty acid transport protein-2 and -4 in the murine placenta. PLoS ONE, 6 (10).

Published Version
Available under License : See the attached license file.

Download (589kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Background: The uptake and trans-placental trafficking of fatty acids from the maternal blood into the fetal circulation are essential for embryonic development, and involve several families of proteins. Fatty acid transport proteins (FATPs) uniquely transport fatty acids into cells. We surmised that placental FATPs are germane for fetal growth, and are regulated during hypoxic stress, which is associated with reduced fat supply to the fetus. Methodology/Principal Findings: Using cultured primary term human trophoblasts we found that FATP2, FATP4 and FATP6 were highly expressed in trophoblasts. Hypoxia enhanced the expression of trophoblastic FATP2 and reduced the expression of FATP4, with no change in FATP6. We also found that Fatp2 and Fatp4 are expressed in the mouse amnion and placenta, respectively. Mice deficient in Fatp2 or Fatp4 did not deviate from normal Mendelian distribution, with both embryos and placentas exhibiting normal weight and morphology, triglyceride content, and expression of genes related to fatty acid mobilization. Conclusions/Significance: We conclude that even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth. © 2011 Mishima et al.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Mishima, Ttam63@pitt.eduTAM63
Miner, JH
Morizane, M
Stahl, A
Sadovsky, Yyoel.sadovsky@pitt.eduYOS14
ContributionContributors NameEmailPitt UsernameORCID
Date: 25 October 2011
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 6
Number: 10
DOI or Unique Handle: 10.1371/journal.pone.0025865
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
Refereed: Yes
MeSH Headings: Animals; Cell Hypoxia; Coenzyme A Ligases--genetics; Coenzyme A Ligases--metabolism; Fatty Acid Transport Proteins--genetics; Fatty Acid Transport Proteins--metabolism; Female; Gene Expression Regulation; Humans; Mice; Mutation; Placenta--cytology; Placenta--metabolism; Pregnancy; Trophoblasts--cytology; Trophoblasts--metabolism
Other ID: NLM PMC3197585
PubMed Central ID: PMC3197585
PubMed ID: 22028793
Date Deposited: 07 Sep 2012 20:45
Last Modified: 17 May 2021 10:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item