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Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing

Ko, SH and Nauta, A and Morrison, SD and Zhou, H and Zimmermann, A and Gurtner, GC and Ding, S and Longaker, MT (2011) Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing. PLoS ONE, 6 (11).

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Abstract

Diabetic wounds remain a major medical challenge with often disappointing outcomes despite the best available care. An impaired response to tissue hypoxia and insufficient angiogenesis are major factors responsible for poor healing in diabetic wounds. Here we show that the antimycotic drug ciclopirox olamine (CPX) can induce therapeutic angiogenesis in diabetic wounds. Treatment with CPX in vitro led to upregulation of multiple angiogenic genes and increased availability of HIF-1α. Using an excisional wound splinting model in diabetic mice, we showed that serial topical treatment with CPX enhanced wound healing compared to vehicle control treatment, with significantly accelerated wound closure, increased angiogenesis, and increased dermal cellularity. These findings offer a promising new topical pharmacologic therapy for the treatment of diabetic wounds. © 2011 Ko et al.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ko, SH
Nauta, A
Morrison, SD
Zhou, H
Zimmermann, A
Gurtner, GC
Ding, S
Longaker, MT
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorMcNeil, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 18 November 2011
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 6
Number: 11
DOI or Unique Handle: 10.1371/journal.pone.0027844
Schools and Programs: School of Medicine > Surgery
Refereed: Yes
MeSH Headings: Animals; Antifungal Agents--pharmacology; Blotting, Western; Cell Line; Diabetes Mellitus--physiopathology; Gene Expression Regulation--drug effects; Human Umbilical Vein Endothelial Cells--drug effects; Human Umbilical Vein Endothelial Cells--metabolism; Human Umbilical Vein Endothelial Cells--physiology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit--metabolism; Mice; NIH 3T3 Cells; Neovascularization, Physiologic--drug effects; Neovascularization, Physiologic--genetics; Neovascularization, Physiologic--physiology; Pyridones--pharmacology; Reverse Transcriptase Polymerase Chain Reaction; Skin--drug effects; Skin--pathology; Skin--physiopathology; Time Factors; Vascular Endothelial Growth Factor A--genetics; Vascular Endothelial Growth Factor A--metabolism; Wound Healing--drug effects; Wound Healing--physiology
Other ID: NLM PMC3220686
PubMed Central ID: PMC3220686
PubMed ID: 22125629
Date Deposited: 07 Sep 2012 19:47
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/13998

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