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Pneumococcal resistance and serotype 19a in Pittsburgh-area children with acute otitis media before and after introduction of 7-valent Pneumococcal polysaccharide vaccine

Hoberman, A and Paradise, JL and Shaikh, N and Greenberg, DP and Kearney, DH and Colborn, DK and Rockette, HE and Kurs-Lasky, M and McEllistrem, MC and Zoffel, LM and Balentine, TL and Barbadora, KA and Wald, ER (2011) Pneumococcal resistance and serotype 19a in Pittsburgh-area children with acute otitis media before and after introduction of 7-valent Pneumococcal polysaccharide vaccine. Clinical Pediatrics, 50 (2). 114 - 120. ISSN 0009-9228

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Abstract

Methods: Before and after introduction of pneumococcal conjugate vaccine (PCV7), the authors obtained nasopharyngeal (NP) specimens from 3 groups of children aged 6 to 23 months with acute otitis media (AOM): group 1 (pre-PCV7), group 2 (early post-PCV7), and group 3 (late post-PCV7). Results: Of the Streptococcus pneumoniae isolates, the proportion that were vaccine serotypes (VTs) declined progressively (60.4% vs 48.6% vs 5.2% in groups 1, 2, and 3, respectively; P <.001). Concurrently, increases occurred in the proportion of penicillin-nonsusceptible isolates (minimum inhibitory concentration >0.1 μg/mL; 26.7% vs 37.8% vs. 38.5%; P =.12); the proportion of isolates that were serotype 19A (4.0% vs 0% vs 25.9%; P <.001); and the proportion of 19A isolates that were penicillin-nonsusceptible (0% in group 1, 68.6% in group 3; P =.004). Conclusion: Shifts in pneumococcal serotype distribution and increases in penicillin nonsusceptibility among pneumococcal isolates from children with AOM underscore the need for continuing bacteriological surveillance for future vaccine development. © The Author(s) 2011.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hoberman, Aalejo@pitt.eduALEJO
Paradise, JL
Shaikh, Nnas67@pitt.eduNAS67
Greenberg, DP
Kearney, DH
Colborn, DK
Rockette, HE
Kurs-Lasky, M
McEllistrem, MC
Zoffel, LM
Balentine, TL
Barbadora, KA
Wald, ER
Date: 1 February 2011
Date Type: Publication
Journal or Publication Title: Clinical Pediatrics
Volume: 50
Number: 2
Page Range: 114 - 120
DOI or Unique Handle: 10.1177/0009922810384259
Schools and Programs: Graduate School of Public Health > Biostatistics
School of Medicine > Pediatrics
Refereed: Yes
ISSN: 0009-9228
MeSH Headings: Acute Disease; Drug Resistance, Bacterial; Female; Humans; Infant; Male; Nasopharynx--microbiology; Otitis Media--immunology; Otitis Media--microbiology; Pneumococcal Infections--microbiology; Pneumococcal Infections--prevention & control; Pneumococcal Vaccines--administration & dosage; Pneumococcal Vaccines--immunology; Serotyping; Streptococcus pneumoniae--classification; Streptococcus pneumoniae--isolation & purification; Vaccination
PubMed ID: 21098526
Date Deposited: 10 Sep 2012 14:44
Last Modified: 02 Feb 2019 16:56
URI: http://d-scholarship.pitt.edu/id/eprint/14024

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