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Prevalence of streptococcal pharyngitis and streptococcal carriage in children: A meta-analysis

Shaikh, N and Leonard, E and Martin, JM (2010) Prevalence of streptococcal pharyngitis and streptococcal carriage in children: A meta-analysis. Pediatrics, 126 (3). ISSN 0031-4005

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OBJECTIVES: Prevalence estimates can help clinicians make informed decisions regarding diagnostic testing of children who present with symptoms of pharyngitis. We conducted a meta-analysis to determine the (1) prevalence of streptococcal infection among children who presented with sore throat and (2) prevalence of streptococcal carriage among asymptomatic children. METHODS: We searched Medline for articles on pediatric streptococcal pharyngitis. We included articles in our review when they contained data on the prevalence of group A Streptococcus (GAS) from pharyngeal specimens in children who were younger than 18 years. Two evaluators independently reviewed, rated, and abstracted data from each article. Prevalence estimates were pooled in a meta-analysis and stratified according to age group. RESULTS: Of the 266 articles retrieved, 29 met all inclusion criteria. Among children of all ages who present with sore throat, the pooled prevalence of GAS was 37% (95% confidence interval [CI]: 32%-43%). Children who were younger than 5 years had a lower prevalence of GAS (24% [95% CI: 21%-26%]). The prevalence of GAS carriage among well children with no signs or symptoms of pharyngitis was 12% (95% CI: 9%-14%). CONCLUSIONS: Prevalence rates of GAS disease and carriage varied by age; children who were younger than 5 years had lower rates of throat cultures that were positive for GAS. Copyright © 2010 by the American Academy of Pediatrics.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Shaikh, Nnas67@pitt.eduNAS67
Leonard, E
Martin, JM
Date: 1 September 2010
Date Type: Publication
Journal or Publication Title: Pediatrics
Volume: 126
Number: 3
DOI or Unique Handle: 10.1542/peds.2009-2648
Schools and Programs: School of Medicine > Pediatrics
Refereed: Yes
ISSN: 0031-4005
Related URLs:
MeSH Headings: Adolescent; Carrier State--epidemiology; Child; Child, Preschool; Humans; Infant; Pharyngitis--epidemiology; Pharyngitis--microbiology; Prevalence; Streptococcal Infections--epidemiology; Streptococcus pyogenes--isolation & purification
PubMed ID: 20696723
Date Deposited: 11 Sep 2012 21:07
Last Modified: 04 Feb 2019 15:57


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