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Development of a patient-reported outcome measure for children with streptococcal pharyngitis

Shaikh, N and Martin, JM and Casey, JR and Pichichero, ME and Wald, ER and Colborn, DK and Gerber, MA and Kearney, DH and Balentine, TL and Haralam, MA and Hoberman, A (2009) Development of a patient-reported outcome measure for children with streptococcal pharyngitis. Pediatrics, 124 (4). ISSN 0031-4005

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OBJECTIVE: The objective of this study was to develop a patient-reported outcome measure (Strep-PRO) for assessing symptoms of group A Streptococcus (GAS) pharyngitis from the child's point of view and to present preliminary data on its internal reliability, construct validity, and responsiveness. METHODS: We selected 8 symptoms for inclusion in the Strep-PRO. We used the Strep-PRO to assess improvement in children who were aged 5 to 15 years and had confirmed GAS pharyngitis. Children completed the scale at study visits and as a diary at home. To evaluate internal reliability, we examined correlations between the items on the scale. To evaluate construct validity, we examined the correlation at entry between Strep-PRO scores and scores on other, previously validated measures of pain and functional status. To evaluate responsiveness, we examined the change in score from enrollment to follow-up. The correlation between the Strep-PRO score and parental assessment of symptoms was also evaluated. RESULTS: A total of 131 children were enrolled; 113 returned completed diaries. The internal reliability of the scale was high. The magnitude of correlations between Strep-PRO scores and other measures of pain and functional status ranged from 0.39 to 0.63. The responsiveness of the Strep-PRO was very good. The overall level of agreement between child Strep-PRO scores and parental assessment of symptoms was 0.57. CONCLUSIONS: The scale seems to measure effectively both pain and overall functional status in children with GAS pharyngitis. These data support the use of Strep-PRO as a measure of outcome in future clinical trials. Copyright © 2009 by the American Academy of Pediatrics.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Shaikh, Nnas67@pitt.eduNAS67
Martin, JM
Casey, JR
Pichichero, ME
Wald, ER
Colborn, DK
Gerber, MA
Kearney, DH
Balentine, TL
Haralam, MA
Hoberman, A
Date: 13 October 2009
Date Type: Publication
Journal or Publication Title: Pediatrics
Volume: 124
Number: 4
DOI or Unique Handle: 10.1542/peds.2009-0331
Schools and Programs: School of Medicine > Pediatrics
Refereed: Yes
ISSN: 0031-4005
Related URLs:
MeSH Headings: Adolescent; Age Factors; Anti-Bacterial Agents--therapeutic use; Child; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Male; Medical Records; Observer Variation; Outcome Assessment (Health Care); Pain Measurement; Patient Participation; Pharyngitis--diagnosis; Pharyngitis--drug therapy; Questionnaires; Reproducibility of Results; Risk Assessment; Severity of Illness Index; Sex Factors; Streptococcal Infections--diagnosis; Streptococcal Infections--drug therapy; Streptococcus pyogenes--isolation & purification
PubMed ID: 19786423
Date Deposited: 11 Sep 2012 21:09
Last Modified: 02 Feb 2019 16:56


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