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Prevalence of urinary tract infection in childhood: A meta-analysis

Shaikh, N and Morone, NE and Bost, JE and Farrell, MH (2008) Prevalence of urinary tract infection in childhood: A meta-analysis. Pediatric Infectious Disease Journal, 27 (4). 302 - 308. ISSN 0891-3668

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BACKGROUND: Knowledge of baseline risk of urinary tract infection can help clinicians make informed diagnostic and therapeutic decisions. We conducted a meta-analysis to determine the pooled prevalence of urinary tract infection (UTI) in children by age, gender, race, and circumcision status. METHODS: MEDLINE and EMBASE databases were searched for articles about pediatric urinary tract infection. Search terms included urinary tract infection, cystitis, pyelonephritis, prevalence and incidence. We included articles in our review if they contained data on the prevalence of UTI in children 0-19 years of age presenting with symptoms of UTI. Of the 51 articles with data on UTI prevalence, 18 met all inclusion criteria. Two evaluators independently reviewed, rated, and abstracted data from each article. RESULTS: Among infants presenting with fever, the overall prevalence (and 95% confidence interval) of UTI was 7.0% (CI: 5.5-8.4). The pooled prevalence rates of febrile UTIs in females aged 0-3 months, 3-6 months, 6-12 months, and >12 months was 7.5%, 5.7%, 8.3%, and 2.1% respectively. Among febrile male infants less than 3 months of age, 2.4% (CI: 1.4-3.5) of circumcised males and 20.1% (CI: 16.8-23.4) of uncircumcised males had a UTI. For the 4 studies that reported UTI prevalence by race, UTI rates were higher among white infants 8.0% (CI: 5.1-11.0) than among black infants 4.7% (CI: 2.1-7.3). Among older children (<19 years) with urinary symptoms, the pooled prevalence of UTI (both febrile and afebrile) was 7.8% (CI: 6.6-8.9). CONCLUSIONS: Prevalence rates of UTI varied by age, gender, race, and circumcision status. Uncircumcised male infants less than 3 months of age and females less than 12 months of age had the highest baseline prevalence of UTI. Prevalence estimates can help clinicians make informed decisions regarding diagnostic testing in children presenting with signs and symptoms of urinary tract infection. © 2008 Lippincott Williams & Wilkins, Inc.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Shaikh, Nnas67@pitt.eduNAS67
Morone, NE
Bost, JE
Farrell, MH
Date: 1 January 2008
Date Type: Publication
Journal or Publication Title: Pediatric Infectious Disease Journal
Volume: 27
Number: 4
Page Range: 302 - 308
DOI or Unique Handle: 10.1097/inf.0b013e31815e4122
Schools and Programs: School of Medicine > Pediatrics
Refereed: Yes
ISSN: 0891-3668
Related URLs:
MeSH Headings: Adolescent; Age Factors; Child; Child, Preschool; Circumcision, Male; Ethnic Groups; Female; Humans; Infant; Infant, Newborn; Male; Prevalence; Risk Factors; Sex Factors; Urinary Tract Infections--epidemiology
PubMed ID: 18316994
Date Deposited: 11 Sep 2012 21:31
Last Modified: 04 Feb 2019 15:58


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