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Effects of a vegetarian diet and treatment preference on biochemical and dietary variables in overweight and obese adults: A randomized clinical trial

Burke, LE and Hudson, AG and Warziski, MT and Styn, MA and Music, E and Elci, OU and Sereika, SM (2007) Effects of a vegetarian diet and treatment preference on biochemical and dietary variables in overweight and obese adults: A randomized clinical trial. American Journal of Clinical Nutrition, 86 (3). 588 - 596. ISSN 0002-9165

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Background: A vegetarian diet may lead to numerous health benefits, including weight loss. Objective: We examined the joint effects of personal preference of dietary treatment and a calorie-restricted, low-fat lactoovovegetarian diet (LOV-D) compared with a standard calorie-restricted, low-fat omnivorous diet (STD-D) on changes in weight, total cholesterol, ratio of LDL to HDL cholesterol (LDL:HDL cholesterol), triacylglycerols, insulin resistance, and macronutrient intake during an 18-mo study. Design: This was a randomized clinical trial of 176 overweight and obese adults who were recruited and randomly assigned first to 1 of 2 preference conditions (yes or no). If assigned to Preference-No, they were randomly assigned to 1 of the 2 diet conditions (STD-D or LOV-D). If assigned to Preference-Yes, they were assigned to the diet they indicated as preferred at screening. The 12-mo intervention was followed by a 6-mo maintenance phase. Results: Participants were mainly women (86.9%) and white (70.5%); 75% completed the 18-mo study. A significant interaction between preference and dietary treatment was not observed for any of the outcome variables. However, participants in the Preference-No groups significantly decreased their triacylglycerols (P = 0.04). The only effect observed for diet was a borderline significant decrease in LDL:HDL cholesterol for the LOV-D group (P = 0.06). Within the LOV-D groups, those who were 100% adherent to the LOV-D had significant and marginally significant reductions in monounsaturated fat (P = 0.02) and total fat (P = 0.05) intakes at 18 mo. Conclusions: Our findings suggest that neither prescribing a vegetarian diet nor allowing persons to choose their preferred diet had a significant effect on outcome measures. However, all participants had a significant reduction in total energy and fat intakes and an increase in energy expenditure, which was reflected in reduced body weight. This clinical trial was registered at as NCT00330629. © 2007 American Society for Nutrition.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Burke, LElbu100@pitt.eduLBU1000000-0003-2434-9867
Hudson, AG
Warziski, MT
Styn, MA
Music, E
Elci, OU
Sereika, SMssereika@pitt.eduSSEREIKA
Date: 1 September 2007
Date Type: Publication
Journal or Publication Title: American Journal of Clinical Nutrition
Volume: 86
Number: 3
Page Range: 588 - 596
DOI or Unique Handle: 10.1093/ajcn/86.3.588
Schools and Programs: School of Nursing > Nursing
Refereed: Yes
ISSN: 0002-9165
MeSH Headings: Adult; Blood Chemical Analysis; Body Mass Index; Cholesterol--blood; Cholesterol, HDL--blood; Cholesterol, LDL--blood; Diet, Fat-Restricted; Diet, Reducing; Diet, Vegetarian; Exercise--physiology; Female; Follow-Up Studies; Food Preferences; Humans; Insulin Resistance; Male; Middle Aged; Obesity--blood; Obesity--diet therapy; Overweight--blood; Overweight--diet therapy; Patient Compliance; Time Factors; Treatment Outcome; Triglycerides--blood
PubMed ID: 17823421
Date Deposited: 18 Sep 2012 15:05
Last Modified: 26 Jan 2022 12:55


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