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Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis

Vieira, AR (2003) Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis. Journal of Dental Research, 82 (3). 162 - 165. ISSN 0022-0345

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Genetic defects responsible for tooth agenesis are only now beginning to be uncovered. MSX1 and PAX9 have been associated with tooth agenesis in mice and humans, but interestingly for humans, these genes are associated with specific missing teeth. Mouse models also show that specific genes contribute to the development of specific types of teeth. A precise description of the phenotype specifying which teeth are missing has become fundamental. Mendelian segregation can be identified in families with tooth agenesis, but heterogenous or multiple genes may be responsible for the development of specific types of teeth agenesis in humans. Data from animal models are still very complex, and the human embryology is still poorly understood. Oral clefts and syndromic forms of tooth agenesis may be the best models for isolated tooth agenesis. In the future, a precise description of the missing teeth in syndromes involving tooth agenesis may be useful.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Vieira, ARarv11@pitt.eduARV11
Date: 1 January 2003
Date Type: Publication
Journal or Publication Title: Journal of Dental Research
Volume: 82
Number: 3
Page Range: 162 - 165
DOI or Unique Handle: 10.1177/154405910308200303
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0022-0345
MeSH Headings: Animals; Anodontia--complications; Anodontia--genetics; Cleft Lip--complications; Cleft Lip--genetics; Cleft Palate--complications; Cleft Palate--genetics; DNA-Binding Proteins--genetics; Homeodomain Proteins--genetics; Humans; MSX1 Transcription Factor; Mice; Models, Genetic; Molar--abnormalities; PAX9 Transcription Factor; Syndrome; Transcription Factors--genetics
PubMed ID: 12598542
Date Deposited: 18 Sep 2012 15:01
Last Modified: 20 Feb 2020 13:55


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