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Inheritance of cleft palate in south america: Evidence for a major locus recessive

Vieira, AR and Romitti, PA and Orioli, IM and Castilla, EE (2003) Inheritance of cleft palate in south america: Evidence for a major locus recessive. Orthodontics and Craniofacial Research, 6 (2). 83 - 87. ISSN 1601-6335

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Abstract

Objectives: Determine the model of inheritance of nonsyndromic cleft palate in humans. Design: Complex segregation analysis performed in families of consecutive newborns affected with non-syndromic cleft palate. Setting and Sample Population: The Latin American Collaborative Study of Congenital Malformations (ECLAMC). Four hundred and seven consecutive newborns affected with non-syndromic cleft palate registered during the period 1967-97. Outcome Measure: Likelihood ratio test and Akaike information criterion (AIC) values. Results: The single major locus recessive model provided a significantly better explanation of the data. It was the most parsimonious and had the smallest AIC value of the six models tested with approximately the same likelihood as the general model (X2 = 2.44, p = 0.5). Conclusions: To have defined a genetic model for nonsyndromic cleft palate and provided evidence for a single major locus inheritance suggests that genetic linkage studies could be implemented. © 2003 Blackwell Munksgaard.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Vieira, ARalexandre_vieira@pitt.eduARV11
Romitti, PA
Orioli, IM
Castilla, EE
Date: 1 December 2003
Date Type: Publication
Journal or Publication Title: Orthodontics and Craniofacial Research
Volume: 6
Number: 2
Page Range: 83 - 87
DOI or Unique Handle: 10.1034/j.1600-0854.2003.02c214.x
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 1601-6335
MeSH Headings: Cleft Palate--epidemiology; Cleft Palate--genetics; Female; Genes, Recessive; Humans; Infant, Newborn; Inheritance Patterns; Likelihood Functions; Logistic Models; Male; Models, Genetic; Pedigree; South America--epidemiology
PubMed ID: 12809269
Date Deposited: 18 Sep 2012 15:03
Last Modified: 02 Feb 2019 14:56
URI: http://d-scholarship.pitt.edu/id/eprint/14215

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