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Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997.

Vieira, AR and Romitti, PA and Orioli, IM and Castilla, EE (2003) Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997. Pesquisa odontológica brasileira = Brazilian oral research, 17 (2). 161 - 165. ISSN 1806-8324

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Abstract

Although several studies have demonstrated familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL/P), its model of inheritance remains uncertain. We report the results of complex segregation analysis performed in South American families with a newborn affected with CL/P. Families of 1,792 consecutive newborns affected with CL/P and registered during the period 1967 to 1997 were studied. A model that did not include a major locus was the best-fitting model for CL/P families. This result is in agreement with previous studies which showed a significant association of several putative susceptibility loci and CL/P, indicating that the genes involved in CL/P are likely to have only a very modest impact on disease risk.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Vieira, ARalexandre_vieira@pitt.eduARV11
Romitti, PA
Orioli, IM
Castilla, EE
Date: 1 January 2003
Date Type: Publication
Journal or Publication Title: Pesquisa odontológica brasileira = Brazilian oral research
Volume: 17
Number: 2
Page Range: 161 - 165
DOI or Unique Handle: 10.1590/s1517-74912003000200012
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 1806-8324
MeSH Headings: Cleft Lip--epidemiology; Cleft Lip--genetics; Cleft Palate--epidemiology; Cleft Palate--genetics; Genetic Predisposition to Disease; Humans; Infant, Newborn; Multifactorial Inheritance; South America--epidemiology
PubMed ID: 14569360
Date Deposited: 18 Sep 2012 15:04
Last Modified: 02 Feb 2019 14:56
URI: http://d-scholarship.pitt.edu/id/eprint/14216

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