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Birth order and neural tube defects: A reappraisal

Vieira, AR (2004) Birth order and neural tube defects: A reappraisal. Journal of the Neurological Sciences, 217 (1). 65 - 72. ISSN 0022-510X

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There is evidence that late birth order is associated with some complex disorders. For neural tube defects (NTDs) there is no consensus as to whether first or increased birth order is associated or not. A meta-analysis of published data on NTDs was carried out to ascertain whether there is an increased risk for children first born or of high birth order to have NTDs. All data available with information regarding the frequency of live births and NTDs cases by birth order (1, 2, 3, and 4 or more) were included in the analysis. Effect sizes calculations were performed. Children with higher birth order are more likely to have spina bifida but not anencephaly. This same effect was also seen for all NTDs combined, which probably reflects the association with spina bifida. These results suggest the compilation of anencephaly and spina bifida data can be the explanation for the controversies seen in the literature. © 2003 Elsevier B.V. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Vieira, ARarv11@pitt.eduARV11
Date: 15 January 2004
Date Type: Publication
Journal or Publication Title: Journal of the Neurological Sciences
Volume: 217
Number: 1
Page Range: 65 - 72
DOI or Unique Handle: 10.1016/j.jns.2003.08.014
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0022-510X
MeSH Headings: Anencephaly--epidemiology; Anencephaly--etiology; Birth Order; Birth Weight; Child; Female; Humans; Incidence; Male; Neural Tube Defects--diagnosis; Neural Tube Defects--epidemiology; Neural Tube Defects--physiopathology; Population Surveillance; Prevalence; Risk Factors; Spinal Dysraphism--epidemiology; Spinal Dysraphism--etiology
PubMed ID: 14675612
Date Deposited: 18 Sep 2012 14:53
Last Modified: 20 Feb 2020 13:55


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