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[Maternal age and neural tube defects: evidence for a greater effect in spina bifida than in anencephaly]. Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia.

Vieira, Alexandre R and Castillo Taucher, Silvia (2005) [Maternal age and neural tube defects: evidence for a greater effect in spina bifida than in anencephaly]. Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia. Revista médica de Chile, 133 (1). 62 - 70. ISSN 0034-9887

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Abstract

BACKGROUND: Recent evidence from birth order data suggest that maternal factors can differently influence anencephaly and spina bifida. AIM: To study the influence of maternal age on the risk for neural tube defects. MATERIAL AND METHODS: A meta-analysis of published data on neural tube defects (NTDs) was carried out to determine whether there is an increased risk to have a child with NTDs for younger and older mothers and if this risk differs depending on the type of NTD. All data available with information regarding the frequency of live births and NTDs cases by maternal age (five- or ten-year intervals) were included in the analysis. Effect sizes calculations were performed. RESULTS: The analysis supports the hypothesis that there is an increased risk of having an offspring with NTDs for mothers 40 years of age or older. However, this effect is stronger for spina bifida than for anencephaly. There is also evidence that mothers 19 years old or younger have a higher risk for having a child with spina bifida. CONCLUSIONS: Maternal age influences the risk of having an offspring with neural tube defects.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Vieira, Alexandre Ralexandre_vieira@pitt.eduARV11
Castillo Taucher, Silvia
Date: January 2005
Date Type: Publication
Journal or Publication Title: Revista médica de Chile
Volume: 133
Number: 1
Page Range: 62 - 70
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0034-9887
Article Type: Research Article
MeSH Headings: Adolescent; Anencephaly--etiology; Female; Humans; Maternal Age; Neural Tube Defects--etiology; Pregnancy; Risk Factors; Spinal Dysraphism--etiology
PubMed ID: 15768151
Date Deposited: 18 Sep 2012 15:53
Last Modified: 30 Oct 2018 14:00
URI: http://d-scholarship.pitt.edu/id/eprint/14222

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