Vieira, AR
(2006)
Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: A HuGE review.
American Journal of Epidemiology, 163 (9).
790 - 810.
ISSN 0002-9262
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Abstract
Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor. Since the first report of an association between DNA sequence variants at the TGFA genetic locus and nonsyndromic oral clefts, 47 studies have been carried out, producing conflicting results. In this review, the author synthesizes findings from published reports on the association between the TGFA gene and clefting in humans. Bias, lack of statistical power, and genuine population diversity can explain the diverse results. In the aggregate, TGFA is probably a genetic modifier of clefting in humans, which is consistent with the oligogenic model suggested for nonsyndromic oral clefts. Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
|
Date: |
10 May 2006 |
Date Type: |
Publication |
Journal or Publication Title: |
American Journal of Epidemiology |
Volume: |
163 |
Number: |
9 |
Page Range: |
790 - 810 |
DOI or Unique Handle: |
10.1093/aje/kwj103 |
Schools and Programs: |
School of Dental Medicine > Dental Science |
Refereed: |
Yes |
ISSN: |
0002-9262 |
Article Type: |
Review |
MeSH Headings: |
Cleft Lip--epidemiology; Cleft Lip--genetics; Cleft Palate--epidemiology; Cleft Palate--genetics; DNA--genetics; Genetic Predisposition to Disease; Humans; Prevalence; Transforming Growth Factor alpha--genetics; Transforming Growth Factor alpha--metabolism |
PubMed ID: |
16495466 |
Date Deposited: |
20 Sep 2012 20:36 |
Last Modified: |
20 Feb 2020 13:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/14225 |
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