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Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: A HuGE review

Vieira, AR (2006) Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: A HuGE review. American Journal of Epidemiology, 163 (9). 790 - 810. ISSN 0002-9262

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Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor. Since the first report of an association between DNA sequence variants at the TGFA genetic locus and nonsyndromic oral clefts, 47 studies have been carried out, producing conflicting results. In this review, the author synthesizes findings from published reports on the association between the TGFA gene and clefting in humans. Bias, lack of statistical power, and genuine population diversity can explain the diverse results. In the aggregate, TGFA is probably a genetic modifier of clefting in humans, which is consistent with the oligogenic model suggested for nonsyndromic oral clefts. Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Vieira, ARarv11@pitt.eduARV11
Date: 10 May 2006
Date Type: Publication
Journal or Publication Title: American Journal of Epidemiology
Volume: 163
Number: 9
Page Range: 790 - 810
DOI or Unique Handle: 10.1093/aje/kwj103
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0002-9262
Article Type: Review
MeSH Headings: Cleft Lip--epidemiology; Cleft Lip--genetics; Cleft Palate--epidemiology; Cleft Palate--genetics; DNA--genetics; Genetic Predisposition to Disease; Humans; Prevalence; Transforming Growth Factor alpha--genetics; Transforming Growth Factor alpha--metabolism
PubMed ID: 16495466
Date Deposited: 20 Sep 2012 20:36
Last Modified: 20 Feb 2020 13:55


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