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The FaceBase Consortium: A comprehensive program to facilitate craniofacial research

Hochheiser, Harry and Aronow, Bruce J and Artinger, Kristin and Beaty, Terri H and Brinkley, James F and Chai, Yang and Fraser, Scott E and Hallgrimsson, Benedikt and Iwata, Junichi and Klein, Ophir and Marazita, Mary L and Murray, Jeffrey C and Murray, Stephen and Pardo-Manuel de Villena, Fernando and Postlethwait, John and Potter, Steven and Shapiro, Linda and Spritz, Richard and Visel, Axel and Weinberg, Seth M and Trainor, Paul A (2012) The FaceBase Consortium: A comprehensive program to facilitate craniofacial research. Developmental Biology, 355 (2). 175 - 182.

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Abstract

The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub. Funded by the National Institute of Dental and Craniofacial Research (NIDCR) and currently focused on studying the development of the middle region of the face, the Consortium will produce comprehensive datasets of global gene expression patterns, regulatory elements and sequencing; will generate anatomical and molecular atlases; will provide human normative facial data and other phenotypes; conduct follow up studies of a completed genome-wide association study; generate independent data on the genetics of craniofacial development, build repositories of animal models and of human samples and data for community access and analysis; and will develop software tools and animal models for analyzing and functionally testing and integrating these data. The FaceBase website (http://www.facebase.org) will serve as a web home for these efforts, providing interactive tools for exploring these datasets, together with discussion forums and other services to support and foster collaboration within the craniofacial research community.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hochheiser, Harryharryh@pitt.eduHARRYH0000-0001-8793-9982
Aronow, Bruce J
Artinger, Kristin
Beaty, Terri H
Brinkley, James F
Chai, Yang
Fraser, Scott E
Hallgrimsson, Benedikt
Iwata, Junichi
Klein, Ophir
Marazita, Mary Lmarazita@pitt.eduMARAZITA
Murray, Jeffrey C
Murray, Stephen
Pardo-Manuel de Villena, Fernando
Postlethwait, John
Potter, Steven
Shapiro, Linda
Spritz, Richard
Visel, Axel
Weinberg, Seth Msmwst46@pitt.eduSMWST46
Trainor, Paul A
Centers: Other Centers, Institutes, or Units > Center for Biomedical Informatics
Date: 15 July 2012
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Developmental Biology
Volume: 355
Number: 2
Page Range: 175 - 182
DOI or Unique Handle: 10.1016/j.ydbio.2011.02.033.
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Biomedical Informatics
Refereed: Yes
Official URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC344030...
Funders: NIH()
Article Type: Research Article
PubMed Central ID: PMC 3440302
PubMed ID: 21458441
Date Deposited: 18 Sep 2012 14:22
Last Modified: 01 Nov 2017 13:58
URI: http://d-scholarship.pitt.edu/id/eprint/14250

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