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Defining subphenotypes for oral clefts based on dental development

Letra, A and Menezes, R and Granjeiro, JM and Vieira, AR (2007) Defining subphenotypes for oral clefts based on dental development. Journal of Dental Research, 86 (10). 986 - 991. ISSN 0022-0345

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Individuals with clefts present considerably more dental anomalies than do individuals without clefts. We used dental development to subphenotype clefts with the goal of identifying cleft subgroups that could have specific genetic contributions. We examined 1000 individuals, 500 with clefts and 500 without. We used several clinical features, such as cleft completeness or incompleteness, laterality, and the presence of dental anomalies to assess each individual's cleft status. We performed chi-square and Fisher's exact tests to compare the frequencies of observed anomalies between individuals with and individuals without clefts, and among individuals with different cleft subphenotypes. Agenesis of the lateral incisor on the non-cleft side was the most remarkable observation, and may suggest that such cases could be considered incomplete forms of bilateral clefts of the lip.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Letra, A
Menezes, R
Granjeiro, JM
Vieira, ARarv11@pitt.eduARV11
Date: 1 October 2007
Date Type: Publication
Journal or Publication Title: Journal of Dental Research
Volume: 86
Number: 10
Page Range: 986 - 991
DOI or Unique Handle: 10.1177/154405910708601013
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0022-0345
MeSH Headings: Adolescent; Adult; Alveolar Process--abnormalities; Case-Control Studies; Chi-Square Distribution; Child; Child, Preschool; Cleft Lip--classification; Cleft Lip--complications; Cleft Lip--genetics; Cleft Palate--classification; Cleft Palate--complications; Cleft Palate--genetics; Humans; Incisor--abnormalities; Middle Aged; Odds Ratio; Phenotype; Statistics, Nonparametric; Tooth Abnormalities--etiology
Other ID: NLM NIHMS37204, NLM PMC2222667
PubMed Central ID: PMC2222667
PubMed ID: 17890676
Date Deposited: 20 Sep 2012 21:14
Last Modified: 20 Feb 2020 13:55


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