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Possible association of amelogenin to high caries experience in a guatemalan-mayan population

Deeley, K and Letra, A and Rose, EK and Brandon, CA and Resick, JM and Marazita, ML and Vieira, AR (2008) Possible association of amelogenin to high caries experience in a guatemalan-mayan population. Caries Research, 42 (1). 8 - 13. ISSN 0008-6568

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Abstract

There is evidence for a genetic component in caries susceptibility, but the disease is greatly influenced by environmental factors, which are extremely difficult to control in humans. For the present study, we used DNA samples collected from 110 unrelated, non-cleft individuals older than 12 years of age from Tiquisate, Guatemala: a population with similar cultural, dietary and hygiene habits, similar access to the dentist and fluoride exposure. Forty-four individuals were designated 'very low caries experience' (DMFT ≤2), and 66 were designated 'higher caries experience' (DMFT ≥3). Single-nucleotide polymorphism markers were genotyped in selected candidate genes (ameloblastin, amelogenin, enamelin, tuftelin-1, and tuftelin interacting protein 11) that influence enamel formation. Having at least one copy of the rare amelogenin marker allele was associated with increased age-adjusted caries experience. This association was stronger in individuals with higher DMFT (DMFT ≥20; p = 0.0000001). Our results suggest that variation in amelogenin may contribute to caries susceptibility in the population studied. The approach of comparing individuals with extremely distinct caries experiences could be valuable for decreasing the potential influence of environmental factors on genetic studies of caries. Copyright © 2007 S. Karger AG, Basel.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Deeley, K
Letra, A
Rose, EK
Brandon, CA
Resick, JM
Marazita, MLmarazita@pitt.eduMARAZITA
Vieira, ARarv11@pitt.eduARV11
Date: 1 January 2008
Date Type: Publication
Journal or Publication Title: Caries Research
Volume: 42
Number: 1
Page Range: 8 - 13
DOI or Unique Handle: 10.1159/000111744
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0008-6568
MeSH Headings: Adolescent; Adult; Amelogenin--genetics; Chromosomes, Human, X; DMF Index; Dental Caries--genetics; Dental Caries Susceptibility--genetics; Female; Gene Frequency; Guatemala; Humans; Indians, Central American--genetics; Linear Models; Male; Middle Aged; Polymorphism, Single Nucleotide
Other ID: NLM PMC2814012
PubMed Central ID: PMC2814012
PubMed ID: 18042988
Date Deposited: 20 Sep 2012 21:14
Last Modified: 20 Feb 2020 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/14279

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