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Genome-wide scan finds suggestive caries loci

Vieira, AR and Marazita, ML and Goldstein-McHenry, T (2008) Genome-wide scan finds suggestive caries loci. Journal of Dental Research, 87 (5). 435 - 439. ISSN 0022-0345

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Abstract

Here we report the first genome-wide scan performed for caries. Evidence from twin studies suggests a genetic component to caries. We aimed to identify genetic factors contributing to caries in a population similarly influenced by confounding factors, such as diet, oral hygiene habits, fluoride exposure, and access to dental care. Forty-six families with similar cultural and behavioral habits, and living in the Philippines, were studied, and genome-wide genotype data and DMFT (Decayed, Missing due to caries, Filled Teeth) scores were evaluated. Suggestive loci logarithmic odds (LOD) scores above 2.0 or non-parametric p-values below 0.0009) were found for low caries susceptibility (5q13.3, 14q11.2, and Xq27.1) and high caries susceptibility (13q31.1 and 14q24.3). Genes that may be related to saliva flow and diet preferences are proposed as possible candidates. A protective locus for caries in the X chromosome may explain the gender differences seen in caries frequency.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Vieira, ARarv11@pitt.eduARV11
Marazita, MLmarazita@pitt.eduMARAZITA
Goldstein-McHenry, T
Date: 1 May 2008
Date Type: Publication
Journal or Publication Title: Journal of Dental Research
Volume: 87
Number: 5
Page Range: 435 - 439
DOI or Unique Handle: 10.1177/154405910808700506
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0022-0345
MeSH Headings: Adolescent; Adult; Child; Child, Preschool; DMF Index; Dental Caries--genetics; Genetic Linkage; Genetic Predisposition to Disease--genetics; Genome, Human--genetics; Humans; Lod Score; Middle Aged; Pedigree; Philippines; Statistics, Nonparametric
PubMed ID: 18434572
Date Deposited: 24 Sep 2012 13:47
Last Modified: 20 Feb 2020 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/14284

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