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The many faces of the genetics contribution to temporomandibular joint disorder

Oakley, M and Vieira, AR (2008) The many faces of the genetics contribution to temporomandibular joint disorder. Orthodontics and Craniofacial Research, 11 (3). 125 - 135. ISSN 1601-6335

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Objectives - Review the literature on candidate genes for temporomandibular joint disorder (TMD). Setting and Sample Population - Literature review. Materials and Methods - Two basic approaches were used to obtain literature in any language regarding genes and TMD. First, Medline, Embase, and Science Citation Index databases were searched using the keywords 'temporomandibular joint disorder' and 'temporomandibular joint dysfunction' for studies published from 1966 to 2007. Then, the references list of the studies obtained in the database was also considered. Results - Candidate genes for TMD include genes for individual variations in pain perception, gender and ethnicity, proinflammatory cytokines, female hormones, breakdown of extracellular matrix, and syndromic forms of TMD. Conclusion - Most of the studies on genetic variation contributing to TMD are approaching the disease mainly from an immune-inflammatory perspective. Recent investigations of the genetic variables which may predict identifiable levels of pain perception may uncover new approaches to our traditional treatment modalities for the chronic pain patient. © 2008 Blackwell Munksgaard.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Oakley, Mmoakley@pitt.eduMOAKLEY
Vieira, ARarv11@pitt.eduARV11
Date: 1 August 2008
Date Type: Publication
Journal or Publication Title: Orthodontics and Craniofacial Research
Volume: 11
Number: 3
Page Range: 125 - 135
DOI or Unique Handle: 10.1111/j.1601-6343.2008.00426.x
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 1601-6335
MeSH Headings: Animals; Cytokines--genetics; Gene Expression Profiling; Humans; Pain Threshold; Sex Characteristics; Temporomandibular Joint Disorders--genetics
PubMed ID: 18713149
Date Deposited: 19 Sep 2012 20:59
Last Modified: 20 Feb 2020 13:55


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