Patir, A and Seymen, F and Yildirim, M and Deeley, K and Cooper, ME and Marazita, ML and Vieira, AR
(2008)
Enamel formation genes are associated with high caries experience in Turkish children.
Caries Research, 42 (5).
394 - 400.
ISSN 0008-6568
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Abstract
There is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes and their interaction with Streptococcus mutans levels may contribute to caries. For the present study, we used DNA samples collected from 173 unrelated children from Istanbul: 91 children with 4 or more affected tooth surfaces and 82 caries-free children. Six single-nucleotide polymorphism markers were genotyped in selected candidate genes (ameloblastin, amelogenin, enamelin, tuftelin 1 and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Regression analysis was used for the evaluation of individual gene effects, environmental effects and gene-environment interactions. Overrepresentation of the C allele of the amelogenin marker was seen in cases with dmft scores higher than 8 (p = 0.01) when compared to controls. Also, overrepresentation of the T allele of the ameloblastin marker was seen in cases with dmfs scores higher than 10 (p = 0.05) when compared to controls. In addition, the CT genotype of the tuftelin rs3790506 marker was overrepresented in cases with dmft scores higher than 5 (p = 0.05) and dmfs scores higher than 6 (p = 0.05) compared to controls. The best-fitting model showed that dmfs is increased when the following factors are present: (1) females and both the anterior and posterior teeth are affected simultaneously, (2) when the T allele of the tuftelin rs3790506 is involved, and (3) the C allele of the amelogenin rs17878486 is involved. Our study provides support that genes involved in enamel formation modify caries susceptibility in humans. Copyright © 2008 S. Karger AG, Basel.
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Details
| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
|
| Date: |
1 September 2008 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Caries Research |
| Volume: |
42 |
| Number: |
5 |
| Page Range: |
394 - 400 |
| DOI or Unique Handle: |
10.1159/000154785 |
| Schools and Programs: |
School of Dental Medicine > Dental Science |
| Refereed: |
Yes |
| ISSN: |
0008-6568 |
| MeSH Headings: |
Amelogenesis--genetics; Amelogenin--genetics; Child, Preschool; Cytosine; DMF Index; Dental Caries--microbiology; Dental Caries Susceptibility--genetics; Dental Enamel Proteins--genetics; Environment; Female; Gene Frequency--genetics; Genetic Markers--genetics; Genotype; Humans; Male; Nuclear Proteins; Phenotype; Polymorphism, Single Nucleotide--genetics; Saliva--microbiology; Sex Factors; Streptococcus mutans--isolation & purification; Thymine; Turkey |
| Other ID: |
NLM PMC2820320 |
| PubMed Central ID: |
PMC2820320 |
| PubMed ID: |
18781068 |
| Date Deposited: |
19 Sep 2012 20:58 |
| Last Modified: |
20 Feb 2020 13:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/14314 |
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