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AXIS inhibition protein 2, orofacial clefts and a family history of cancer

Menezes, R and Marazita, ML and McHenry, TG and Cooper, ME and Bardi, K and Brandon, C and Letra, A and Martin, RA and Vlelra, AR (2009) AXIS inhibition protein 2, orofacial clefts and a family history of cancer. Journal of the American Dental Association, 140 (1). 80 - 84. ISSN 0002-8177

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Background. Cancer and congenital malformations occasionally may have a common etiology. The authors investigated whether families with one or more members affected by orofacial clefts (that is, families segregating orofacial clefts) had an increased cancer incidence when compared with control families. Methods. The authors assessed 75 white families with nonsyndromic cleft lip with or without cleft palate (CL/P) and 93 white control families regarding a history of cancer. They used x2 and Fisher exact tests to determine significant differences. They then performed molecular studies with genes in which mutations have been independently associated with both cancer and craniofacial anomalies in a total of 111 families with CL/P. Results. The families with CL/P reported a family history of cancer more often than did control families (P < .001), and they had higher rates of specific cancer types: colon (P < .001), brain (P = .003), leukemia (P = .005), breast (P = .009), prostate (P = .01), skin (P = .01), lung (P = .02) and liver (P = .02). The authors detected overtransmission of AXIS inhibition protein 2 (AXIN2) in CL/P probands (P = .003). Conclusion. Families segregating CL/P may have an increased susceptibility to cancer, notably colon cancer. Furthermore, AXIN2, a gene that when mutated increases susceptibility to colon cancer, also is associated with CL/P. Clinical Implications. People who are at a higher risk of developing disease need to adopt a healthier lifestyle, including avoiding exposure to risk factors that may interact with their genotypes.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Menezes, R
Marazita, MLmarazita@pitt.eduMARAZITA
McHenry, TG
Cooper, ME
Bardi, K
Brandon, C
Letra, A
Martin, RA
Vlelra, AR
Date: 1 January 2009
Date Type: Publication
Journal or Publication Title: Journal of the American Dental Association
Volume: 140
Number: 1
Page Range: 80 - 84
DOI or Unique Handle: 10.14219/jada.archive.2009.0022
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0002-8177
MeSH Headings: Axin Protein; Case-Control Studies; Chi-Square Distribution; Cleft Lip--genetics; Cleft Lip--metabolism; Cleft Palate--genetics; Cleft Palate--metabolism; Colonic Neoplasms--genetics; Colonic Neoplasms--metabolism; Cytoskeletal Proteins--biosynthesis; Cytoskeletal Proteins--genetics; Family Health; Humans; Mutation; Neoplasms--genetics; Neoplasms--metabolism; Polymorphism, Single Nucleotide; Risk Factors
Other ID: NLM NIHMS71199, NLM PMC2945901
PubMed Central ID: PMC2945901
PubMed ID: 19119171
Date Deposited: 20 Sep 2012 20:13
Last Modified: 22 Jun 2021 14:56


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