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Aggressive periodontitis is likely influenced by a few small effect genes

De Carvalho, FM and Tinoco, EMB and Govil, M and Marazita, ML and Vieira, AR (2009) Aggressive periodontitis is likely influenced by a few small effect genes. Journal of Clinical Periodontology, 36 (6). 468 - 473. ISSN 0303-6979

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Aim: To evaluate the inheritance mode of aggressive periodontitis in a collection of families with a similar geographic origin. Materials and Methods: Segregation analysis was performed in pedigree data from 74 families by the use of the SEGREG program of SAGE v.5.4.2. Homogeneous no transmission, homogeneous Mendelian transmission, homogeneous general transmission, semi-general transmission and heterogeneous general transmission models were tested assuming the prevalence of aggressive periodontitis as 1% and no deviations from Hardy-Weinberg equilibrium. The parameters of the model were estimated by the method of maximum likelihood, which provides the overall ln (likelihood), -2ln and the AIC (Akaike's score) for each model. The likelihood ratio test (LRT) was used to compare each model against a fully general model (p>0.05). Results: The most parsimonious mode of inheritance was the semi-general transmission model that allows the heterozygote transmission probability to vary. Conclusion: This result provides strong support for the hypothesis that genetic factors play a role in aggressive periodontitis and that a few loci, each with relatively small effects, contribute to aggressive periodontitis, with or without interaction with environmental factors. © 2009 John Wiley & Sons AS.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
De Carvalho, FM
Tinoco, EMB
Govil, M
Marazita, MLmarazita@pitt.eduMARAZITA
Vieira, ARarv11@pitt.eduARV11
Date: 1 June 2009
Date Type: Publication
Journal or Publication Title: Journal of Clinical Periodontology
Volume: 36
Number: 6
Page Range: 468 - 473
DOI or Unique Handle: 10.1111/j.1600-051x.2009.01410.x
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0303-6979
MeSH Headings: Aggressive Periodontitis--genetics; Alleles; Brazil; Chromosome Segregation--genetics; Female; Gene Frequency; Genetic Heterogeneity; Genetic Predisposition to Disease--genetics; Genetic Variation--genetics; Genotype; Heterozygote; Humans; Likelihood Functions; Male; Models, Genetic; Pedigree; Phenotype
Other ID: NLM NIHMS120879, NLM PMC2731969
PubMed Central ID: PMC2731969
PubMed ID: 19453571
Date Deposited: 20 Sep 2012 20:06
Last Modified: 20 Feb 2020 13:55


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