Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Defining subphenotypes for tooth agenesis: Does side matter?

De Castro Costa, M and Calvano Küchler, E and Garcia Filho, PF and Modesto, A and Vieira, AR (2009) Defining subphenotypes for tooth agenesis: Does side matter? Journal of Clinical Pediatric Dentistry, 34 (2). 169 - 172. ISSN 1053-4628

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Objectives: The etiology of tooth agenesis is still poorly understood. The identification of sub-populations with specific types of hypodontia (subphenotypes) would allow testing the specific hypothesis that certain genetic factors contribute to the specific subphenotype. The aim of this work was assessing a large cohort to verify if preferential tooth agenesis subphenotypes could be identified. Method: Panoramic radiographs of 1052 cases were examined and 1034 were used in this study. The presence of tooth agenesis was assessed in the study population. Results: The frequency of tooth agenesis in the studied population was 3.77%. While bilateral cases did not differ in the frequency of agenesis by arch (p = 0.8), unilateral cases presented more commonly agenesis on the mandibular arch (p = 0.03). This result was clearly driven by the frequency of second premolar agenesis, which was the most common absent tooth in the studied population. Unilateral lower second premolar agenesis was found more often than bilateral agenesis (p = 0.047). Conclusions: Our findings that unilateral lower second premolar agenesis is more common than bilateral agenesis, with a trend for unilateral agenesis being more common on the right side may suggest specific genetic factors may be differentially expressed depending on the side.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
De Castro Costa, M
Calvano Küchler, E
Garcia Filho, PF
Modesto, A
Vieira, ARarv11@pitt.eduARV11
Date: 1 December 2009
Date Type: Publication
Journal or Publication Title: Journal of Clinical Pediatric Dentistry
Volume: 34
Number: 2
Page Range: 169 - 172
DOI or Unique Handle: 10.17796/jcpd.34.2.955j6875745h6607
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 1053-4628
MeSH Headings: Anodontia--genetics; Anodontia--radiography; Bicuspid--abnormalities; Child; Female; Humans; Male; Phenotype
PubMed ID: 20297711
Date Deposited: 20 Sep 2012 19:44
Last Modified: 20 Feb 2020 13:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item