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The antimicrobial peptide DEFB1 is associated with caries

Ozturk, A and Famili, P and Vieira, AR (2010) The antimicrobial peptide DEFB1 is associated with caries. Journal of Dental Research, 89 (6). 631 - 636. ISSN 0022-0345

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Abstract

Genetics is an important component in the determination of individual susceptibility to caries and periodontal diseases. Since beta defensin 1 (DEFB1) localizes in the oral cavity, we tested if variation in DEFB1 is associated with caries and periodontitis. We analyzed 3 single-nucleotide polymorphisms in DEFB1 in DNA samples from unrelated individuals. Carrying a copy of the variant allele of the DEFB1 marker rs11362 (G-20A) increased the DMFT and DMFS scores more than five-fold. Also, carrying a copy of the variant allele of the DEFB1 marker rs179946 (G-52A) correlated with low DMFT scores. We found a high-caries-experience haplotype (GCA), which increased DMFT scores two-fold, and a low-caries-experience haplotype (ACG), which decreased DMFT scores two-fold, in the DEFB1 promoter. No association between DEFB1 genetic markers and periodontal disease was found. Our results suggest that functional polymorphisms of DEFB1 are potential markers for caries.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ozturk, A
Famili, Ppof@pitt.eduPOF
Vieira, ARalexandre_vieira@pitt.eduARV11
Date: 1 January 2010
Date Type: Publication
Journal or Publication Title: Journal of Dental Research
Volume: 89
Number: 6
Page Range: 631 - 636
DOI or Unique Handle: 10.1177/0022034510364491
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0022-0345
MeSH Headings: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Aggressive Periodontitis--genetics; Alleles; Antimicrobial Cationic Peptides--genetics; Cytosine; DMF Index; Dental Caries--genetics; Dental Caries Susceptibility--genetics; Disease Progression; Female; Genetic Markers--genetics; Genetic Variation--genetics; Guanine; Haplotypes; Humans; Linkage Disequilibrium--genetics; Male; Middle Aged; Periodontitis--genetics; Pilot Projects; Polymorphism, Single Nucleotide--genetics; Promoter Regions, Genetic--genetics; Young Adult; beta-Defensins--genetics
PubMed ID: 20371866
Date Deposited: 20 Sep 2012 19:43
Last Modified: 03 Aug 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/14331

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