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Cleft lip and palate in family members of cancer survivors

Taioli, E and Ragin, C and Robertson, L and Linkov, F and Thurman, NE and Vieira, AR (2010) Cleft lip and palate in family members of cancer survivors. Cancer Investigation, 28 (9). 958 - 962. ISSN 0735-7907

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Abstract

The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75-17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P. © 2010 Informa Healthcare USA, Inc.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Taioli, E
Ragin, C
Robertson, L
Linkov, F
Thurman, NE
Vieira, ARalexandre_vieira@pitt.eduARV11
Date: 1 October 2010
Date Type: Publication
Journal or Publication Title: Cancer Investigation
Volume: 28
Number: 9
Page Range: 958 - 962
DOI or Unique Handle: 10.3109/07357907.2010.483510
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0735-7907
MeSH Headings: Adult; Aged; Cleft Lip--epidemiology; Cleft Palate--epidemiology; Comorbidity; Family; Family Health; Female; Humans; Male; Melanoma--epidemiology; Middle Aged; Neoplasms--epidemiology; Pennsylvania--epidemiology; Questionnaires; Survivors--statistics & numerical data; Testicular Neoplasms--epidemiology; Young Adult
PubMed ID: 20569073
Date Deposited: 20 Sep 2012 19:41
Last Modified: 02 Feb 2019 14:56
URI: http://d-scholarship.pitt.edu/id/eprint/14336

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