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Mitochondrial DNA origins of the Latvian clefting population

Vieira, AR and Pliss, L and Pelnena, I and Krumina, A and Baumanis, V and Lace, B (2011) Mitochondrial DNA origins of the Latvian clefting population. Mitochondrion, 11 (2). 357 - 359. ISSN 1567-7249

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Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility. © 2010.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Vieira, ARarv11@pitt.eduARV11
Pliss, L
Pelnena, I
Krumina, A
Baumanis, V
Lace, B
Date: 1 March 2011
Date Type: Publication
Journal or Publication Title: Mitochondrion
Volume: 11
Number: 2
Page Range: 357 - 359
DOI or Unique Handle: 10.1016/j.mito.2010.10.001
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 1567-7249
MeSH Headings: Cleft Lip--genetics; Cleft Palate--genetics; DNA, Mitochondrial--genetics; Genetics, Population; Humans; Latvia
PubMed ID: 20946971
Date Deposited: 24 Sep 2012 20:53
Last Modified: 20 Feb 2020 13:55


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