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MMP1 and MMP20 contribute to tooth agenesis in humans

Küchler, EC and Menezes, R and Callahan, N and Costa, MC and Modesto, A and Meira, R and Patir, A and Seymen, F and Paiva, KBS and Nunes, FD and Granjeiro, JM and Vieira, AR (2011) MMP1 and MMP20 contribute to tooth agenesis in humans. Archives of Oral Biology, 56 (5). 506 - 511. ISSN 0003-9969

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Objective: Variations in genes that are critical for tooth formation may contribute to the tooth agenesis. MMPs are potential candidate genes for dental alterations based on the roles they play during embryogenesis. The aim of this study was to investigate the possible association between MMP1, MMP3, and MMP20 and tooth agenesis. Methods: One hundred sixty-seven nuclear families from two different populations were analysed, 116 from Brazil and 51 from Turkey. Probands had at least one congenitally missing tooth. DNA samples were obtained from blood or saliva samples and genotyping was performed using TaqMan chemistry. In addition, Mmp20 was selected for quantitative real-time polymerase chain reaction analysis with SYBR Green I Dye in mouse tooth development. Results: Associations between tooth agenesis and MMP1 (p = 0.007), and MMP20 (p = 0.03) were found in Brazilian families. In the total dataset, MMP20 continued to be associated with tooth agenesis (p = 0.01). Mmp20 was not expressed during the initial stages of tooth development. Conclusion: Our findings provide evidence that MMP1 and MMP20 play a role in human tooth agenesis. © 2010 Elsevier Ltd. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Küchler, EC
Menezes, R
Callahan, N
Costa, MC
Modesto, A
Meira, R
Patir, A
Seymen, F
Paiva, KBS
Nunes, FD
Granjeiro, JM
Vieira, ARarv11@pitt.eduARV11
Date: 1 May 2011
Date Type: Publication
Journal or Publication Title: Archives of Oral Biology
Volume: 56
Number: 5
Page Range: 506 - 511
DOI or Unique Handle: 10.1016/j.archoralbio.2010.11.007
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0003-9969
MeSH Headings: Analysis of Variance; Animals; Anodontia--genetics; Brazil; Female; Genotype; Humans; Male; Matrix Metalloproteinase 1--genetics; Matrix Metalloproteinase 20--genetics; Matrix Metalloproteinase 3--genetics; Mice; Odontogenesis--genetics; Phenotype; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Turkey
PubMed ID: 21144496
Date Deposited: 24 Sep 2012 20:52
Last Modified: 20 Feb 2020 13:55


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