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Genetic variation in Myosin 1H contributes to mandibular prognathism

Tassopoulou-Fishell, M and Deeley, K and Harvey, EM and Sciote, J and Vieira, AR (2012) Genetic variation in Myosin 1H contributes to mandibular prognathism. American Journal of Orthodontics and Dentofacial Orthopedics, 141 (1). 51 - 59. ISSN 0889-5406

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Introduction: Several candidate loci have been suggested as influencing mandibular prognathism (1p22.1, 1p22.2, 1p36, 3q26.2, 5p13-p12, 6q25, 11q22.2-q22.3, 12q23, 12q13.13, and 19p13.2). The goal of this study was to replicate these results in a well-characterized homogeneous sample set. Methods: Thirty-three single nucleotide polymorphisms spanning all candidate regions were studied in 44 prognathic and 35 Class I subjects from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository. The 44 subjects with mandibular prognathism had an average age of 18.4 years; 31 were female and 13 male; and 24 were white, 15 African American, 2 Hispanic, and 3 Asian. The 36 Class I subjects had an average age of 17.6 years; 27 were female and 9 male; and 27 were white, 6 African American, 1 Hispanic, and 2 Asian. Skeletal mandibular prognathism diagnosis included cephalometric values indicative of Class III such as an ANB smaller than 2°, a negative Wits appraisal, and a positive A-B plane. Additional mandibular prognathism criteria included negative overjet and visually prognathic (concave) profile as determined by the subject's clinical evaluation. Orthognathic subjects without jaw deformations were used as the comparison group. The mandibular prognathic and orthognathic subjects were matched by race, sex, and age. Genetic markers were tested by polymerase chain reaction with TaqMan chemistry. Chi-square and Fisher exact tests were used to determine overrepresentation of marker allele with an alpha of 0.05. Results: An association was unveiled between a marker in MYO1H (rs10850110) and the mandibular prognathism phenotype (P = 0.03). MYO1H is a Class I myosin that is in a different protein group than the myosin isoforms of muscle sarcomeres, which are the basis of skeletal muscle fiber typing. Class I myosins are necessary for cell motility, phagocytosis, and vesicle transport. Conclusions: More strict clinical definitions might increase homogeneity and aid the studies of genetic susceptibility to malocclusions. We provide evidence that MYO1H can contribute to mandibular prognathism.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Tassopoulou-Fishell, M
Deeley, K
Harvey, EM
Sciote, J
Vieira, ARarv11@pitt.eduARV11
Date: 1 January 2012
Date Type: Publication
Journal or Publication Title: American Journal of Orthodontics and Dentofacial Orthopedics
Volume: 141
Number: 1
Page Range: 51 - 59
DOI or Unique Handle: 10.1016/j.ajodo.2011.06.033
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0889-5406
MeSH Headings: Adolescent; Adult; African Americans--genetics; Asian Americans--genetics; Case-Control Studies; Chi-Square Distribution; Child; Chromosomes, Human, Pair 12--genetics; European Continental Ancestry Group--genetics; Female; Humans; Male; Malocclusion, Angle Class III--genetics; Mandible--abnormalities; Middle Aged; Myosin Type I--genetics; Pilot Projects; Polymorphism, Single Nucleotide; Prognathism--genetics; Young Adult
PubMed ID: 22196185
Date Deposited: 24 Sep 2012 19:17
Last Modified: 20 Feb 2020 13:55


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