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Genetic variation in MMP20 contributes to higher caries experience

Tannure, PN and Küchler, EC and Lips, A and Costa, MDC and Luiz, RR and Granjeiro, JM and Vieira, AR (2012) Genetic variation in MMP20 contributes to higher caries experience. Journal of Dentistry, 40 (5). 381 - 386. ISSN 0300-5712

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Matrix metalloproteinases play an important role during the initial process of enamel development and therefore may play a role in caries. Objectives: To evaluate the association between MMP20 and caries experience in Brazilian children. Methods: Eligible unrelated children with or without caries were evaluated using a cohort design. Demographic data and oral health habits were obtained though a questionnaire. Caries data was collected by clinical examination. Genotyping of the selected polymorphism was carried out by real-time PCR from genomic DNA. Allele and genotype frequencies were compared between groups with distinct caries experience and oral health habits. Results: Of 388 subjects, 161 were caries free children. There were no differences between caries levels and genotype distribution in the total cohort. When ethnic background was considered, differences in genotype distribution were observed in caries free children vs. children with caries in Caucasians (p = 0.03). Differences could also be seen when poor oral hygiene was used to stratify the analysis (p = 0.02). Regression analysis, adjusted for genotype and ethnicity, confirmed that ingestion of sweets between meals increases the risk of presenting carious lesions (p = 0.00001; OR = 2.33; 95%CI 1.53-3.54). Conclusion: Variation in MMP20 may be associated with caries experience mainly in Caucasian subjects with poor oral health habits. © 2012 Elsevier Ltd. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Tannure, PN
Küchler, EC
Lips, A
Costa, MDC
Luiz, RR
Granjeiro, JM
Vieira, ARarv11@pitt.eduARV11
Date: 1 May 2012
Date Type: Publication
Journal or Publication Title: Journal of Dentistry
Volume: 40
Number: 5
Page Range: 381 - 386
DOI or Unique Handle: 10.1016/j.jdent.2012.01.015
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0300-5712
Other ID: NLM NIHMS359889, NLM PMC3322296
PubMed Central ID: PMC3322296
PubMed ID: 22330321
Date Deposited: 24 Sep 2012 19:15
Last Modified: 20 Feb 2020 13:55


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