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A preliminary study on the FAM5C expression in generalized chronic periodontitis

Ribeiro, FV and Santos, VR and Bastos, MF and de Miranda, TS and Vieira, AR and de Figueiredo, LC and Duarte, PM (2012) A preliminary study on the FAM5C expression in generalized chronic periodontitis. Oral Diseases, 18 (2). 147 - 152. ISSN 1354-523X

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Objective: The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chronic periodontitis and to study association of FAM5C with key immunoinflammatory markers. Material and Methods: Gingival biopsies were harvested from periodontally healthy subjects (n=10) and chronic periodontitis subjects (n=15). The levels of mRNA of FAM5C, interleukin (IL)-17, IL-6, IL-23, IL-10, IL-4, interferon-γ, toll-like receptor (TLR)-2, TLR-4, osteoprotegerin (OPG), receptor activator of NF- κB ligand (RANKL), tumor necrosis factor (TNF)-α, transforming growth factor-β, transcription factor forkhead box p3, and transcription factor orphan nuclear receptor C2 were evaluated by real-time polymerase chain reaction. Results: FAM5C mRNA levels were not different between periodontally healthy and diseased tissues (P>0.05). Gene expressions of IL-17, TNF-α, OPG, RANKL, TLR-2, and TLR-4 were higher in periodontitis, when compared to periodontally healthy sites (P<0.05), while no differences between groups were observed for the other genes evaluated (P>0.05). There were no correlations between the gene expression of FAM5C and the other immunoinflammatory markers (P>0.05). Conclusion: Within the limits of this study, it seems that FAM5C expression does not contribute to chronic periodontitis. © 2011 John Wiley & Sons A/S.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ribeiro, FV
Santos, VR
Bastos, MF
de Miranda, TS
Vieira, ARarv11@pitt.eduARV11
de Figueiredo, LC
Duarte, PM
Date: 1 March 2012
Date Type: Publication
Journal or Publication Title: Oral Diseases
Volume: 18
Number: 2
Page Range: 147 - 152
DOI or Unique Handle: 10.1111/j.1601-0825.2011.01855.x
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 1354-523X
MeSH Headings: Adult; Case-Control Studies; Chronic Periodontitis--genetics; Chronic Periodontitis--metabolism; Cytokines--biosynthesis; Cytokines--genetics; DNA-Binding Proteins--biosynthesis; DNA-Binding Proteins--genetics; Female; Gene Expression; Gingiva--pathology; Humans; Inflammation Mediators--metabolism; Interleukins--biosynthesis; Interleukins--genetics; Male; Middle Aged; Mitochondrial Proteins--biosynthesis; Mitochondrial Proteins--genetics; Periodontal Index; Pilot Projects; RANK Ligand--biosynthesis; RANK Ligand--genetics; RNA, Messenger--genetics; Real-Time Polymerase Chain Reaction; Statistics, Nonparametric; Toll-Like Receptor 2--biosynthesis; Toll-Like Receptor 2--genetics; Toll-Like Receptor 4--biosynthesis; Toll-Like Receptor 4--genetics; Tumor Necrosis Factor-alpha--biosynthesis; Tumor Necrosis Factor-alpha--genetics
PubMed ID: 22355820
Date Deposited: 24 Sep 2012 19:17
Last Modified: 22 Jun 2021 11:55


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