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MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression

Letra, A and Silva, RM and Rylands, RJ and Silveira, EM and De Souza, AP and Wendell, SK and Garlet, GP and Vieira, AR (2012) MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression. Journal of Clinical Periodontology, 39 (8). 707 - 716. ISSN 0303-6979

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Abstract

Aim Matrix metalloproteinases (MMPs) play a key role in the tissue destruction characteristic of chronic periodontitis. The purpose of this study was to investigate the association of MMP and TIMP polymorphisms with chronic periodontitis in two populations. Material and Methods A total of 34 polymorphisms spanning 12 MMP and 2 TIMP genes were genotyped in 401 individuals from Brazil (99 cases with chronic periodontitis and 302 controls), and 274 individuals from the US (70 cases and 204 controls). Individuals were considered cases if presenting at least three teeth exhibiting sites of clinical attachment loss ≥ 5 mm in two different quadrants. Controls were characterized by absence of clinical attachment loss and no sites with probing depth >3 mm. MMP3 and TIMP1 mRNA expression was evaluated in healthy and diseased periodontal tissues. Results TIMP1 showed association with chronic periodontitis in the Brazilian population (for rs5906435, p = 0.0004), whereas MMP3 showed association in the US population (for rs679620, p = 0.0003; and rs650108, p = 0.002) and in the Brazilian population (for rs639752, p = 0.005). MMP3 and TIMP1 mRNA expression was significantly higher in diseased tissues when compared to control tissues. Conclusions Our results further support a role for variations in MMP3 in chronic periodontitis and report a novel association with TIMP1. These genes may be considered additional candidate genes for chronic periodontitis. © 2012 John Wiley & Sons A/S.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Letra, A
Silva, RM
Rylands, RJ
Silveira, EM
De Souza, AP
Wendell, SKwend0017@pitt.eduWEND0017
Garlet, GP
Vieira, ARalexandre_vieira@pitt.eduARV11
Date: 1 August 2012
Date Type: Publication
Journal or Publication Title: Journal of Clinical Periodontology
Volume: 39
Number: 8
Page Range: 707 - 716
DOI or Unique Handle: 10.1111/j.1600-051x.2012.01902.x
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0303-6979
Other ID: NLM NIHMS373432, NLM PMC3393793
PubMed Central ID: PMC3393793
PubMed ID: 22671570
Date Deposited: 24 Sep 2012 19:10
Last Modified: 02 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/14434

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