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MMP13 polymorphism decreases risk for dental caries

Tannure, PN and Küchler, EC and Falagan-Lotsch, P and Amorim, LMF and Raggio Luiz, R and Costa, MC and Vieira, AR and Granjeiro, JM (2012) MMP13 polymorphism decreases risk for dental caries. Caries Research, 46 (4). 401 - 407. ISSN 0008-6568

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Abstract

Recent evidence suggests that genetic studies may contribute to a better understanding of individual susceptibility to caries. Matrix metalloproteinases (MMPs) and their tissue inhibitors have been suggested to be involved in the caries process. The purpose of this study was to determine if polymorphisms in MMP2 (rs243865), MMP9 (rs17576), MMP13 (rs2252070), and TIMP2 (rs7501477) were associated with caries. Eligible unrelated children and adolescents were evaluated using a cross-sectional design. Data on oral health habits was obtained through a questionnaire and caries data was collected by clinical examination. Genotyping of the selected polymorphisms was carried out by real-time PCR. Allele and genotype frequencies were compared between individuals with and without caries experience. Of 505 subjects, 212 were caries-free and most subjects (61.2%) had mixed dentition. Allele frequency of MMP2, MMP13 and TIMP2 was different between caries-affected and caries-free individuals, with significant association for MMP13 (p = 0.004). Mutant allele carriers for MMP13 demonstrated a significantly decreased risk for caries (OR = 0.538, 95% CI 0.313-0.926); this result remained significant after adjustment for candidate genes, type of dentition and dietary factors. Allelic and genotype frequencies of the polymorphism in MMP9 were similar in caries-affected and caries-free individuals. Genetic variations in MMP13 may contribute to individual differences in caries susceptibility. Our findings reinforce that susceptibility to caries results from gene-environment interactions. Copyright © 2012 S. Karger AG, Basel.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Tannure, PN
Küchler, EC
Falagan-Lotsch, P
Amorim, LMF
Raggio Luiz, R
Costa, MC
Vieira, ARalexandre_vieira@pitt.eduARV11
Granjeiro, JM
Date: 1 July 2012
Date Type: Publication
Journal or Publication Title: Caries Research
Volume: 46
Number: 4
Page Range: 401 - 407
DOI or Unique Handle: 10.1159/000339379
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
ISSN: 0008-6568
PubMed ID: 22710194
Date Deposited: 24 Sep 2012 19:08
Last Modified: 02 Feb 2019 14:56
URI: http://d-scholarship.pitt.edu/id/eprint/14436

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