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Comparative genomics and structure prediction of dental matrix proteins.

Krishnaraju, RK and Hart, TC and Schleyer, TK (2003) Comparative genomics and structure prediction of dental matrix proteins. In: UNSPECIFIED UNSPECIFIED, 100 - 103. ISBN UNSPECIFIED

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Non-collagenous matrix proteins secreted by the ameloblasts (amelogenin) and odontoblasts (osteocalcin) play important roles in the mineralization of enamel and dentin. In this study, comparative genomics approaches were used to identify the functional domains and model the three-dimensional structure of amelogenin and osteocalcin, respectively. Multiple sequence analysis of amelogenin in different species showed a high degree of sequence conservation at the nucleotide and protein levels. At the protein level, motifs (a sequence pattern that occurs repeatedly in a group of related proteins or genes), conserved domains, secondary structural characteristics, and functional sites of amelogenin from lower phyla were similar to those of the higher-level mammals, reflecting the high degree of sequence conservation during vertebrate evolution. Osteocalcin, produced by both odontoblasts and osetoblasts, also showed sequence similarity between species. Three-dimensional structure predictions developed by modeling of conserved domains of osteocalcin supported a role for glutamic acid residues in the calcium mineralization process.


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Item Type: Book Section
Status: Published
CreatorsEmailPitt UsernameORCID
Krishnaraju, RK
Hart, TC
Schleyer, TKtitus@pitt.eduTITUS0000-0003-1829-971X
Centers: Other Centers, Institutes, Offices, or Units > Center for Dental Informatics
Date: 1 January 2003
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Advances in dental research
Volume: 17
Page Range: 100 - 103
Event Type: Conference
DOI or Unique Handle: 10.1177/154407370301700123
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Refereed: Yes
Date Deposited: 02 Oct 2012 18:52
Last Modified: 05 Feb 2019 07:55


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