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Mouse allergen, lung function, and atopy in Puerto Rican children

Forno, E and Cloutier, MM and Datta, S and Paul, K and Sylvia, J and Calvert, D and Thornton-Thompson, S and Wakefield, DB and Brehm, J and Hamilton, RG and Alvarez, M and Colón-Semidey, A and Acosta-Pérez, E and Canino, G and Celedón, JC (2012) Mouse allergen, lung function, and atopy in Puerto Rican children. PLoS ONE, 7 (7).

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Abstract

Objective: To examine the relation between mouse allergen exposure and asthma in Puerto Rican children. Methods: Mus m 1, Der p 1, Bla g 2, and Fel d 1 allergens were measured in dust samples from homes of Puerto Rican children with (cases) and without (controls) asthma in Hartford, CT (n = 449) and San Juan (SJ), Puerto Rico (n = 678). Linear or logistic regression was used for the multivariate analysis of mouse allergen (Mus m 1) and lung function (FEV1 and FEV1/FVC) and allergy (total IgE and skin test reactivity (STR) to ≥1 allergen) measures. Results: Homes in SJ had lower mouse allergen levels than those in Hartford. In multivariate analyses, mouse allergen was associated with higher FEV1 in cases in Hartford (+70.6 ml, 95% confidence interval (CI) = 8.6-132.7 ml, P = 0.03) and SJ (+45.1 ml, 95% CI = -0.5 to 90.6 ml, P = 0.05). In multivariate analyses of controls, mouse allergen was inversely associated with STR to ≥1 allergen in non-sensitized children (odds ratio [OR] for each log-unit increment in Mus m 1 = 0.7, 95% CI = 0.5-0.9, P<0.01). In a multivariate analysis including all children at both study sites, each log-increment in mouse allergen was positively associated with FEV1 (+28.3 ml, 95% CI = 1.4-55.2 ml, P = 0.04) and inversely associated with STR to ≥1 allergen (OR for each log-unit increment in Mus m 1 = 0.8, 95% CI = 0.6-0.9, P<0.01). Conclusions: Mouse allergen is associated with a higher FEV1 and lower odds of STR to ≥1 allergen in Puerto Rican children. This may be explained by the allergen itself or correlated microbial exposures. © 2012 Forno et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Forno, E
Cloutier, MM
Datta, S
Paul, K
Sylvia, J
Calvert, D
Thornton-Thompson, S
Wakefield, DB
Brehm, Jjmb270@pitt.eduJMB270
Hamilton, RG
Alvarez, M
Colón-Semidey, A
Acosta-Pérez, E
Canino, G
Celedón, JC
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorKrauss-Etschmann, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 16 July 2012
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 7
Number: 7
DOI or Unique Handle: 10.1371/journal.pone.0040383
Schools and Programs: School of Medicine > Pediatrics
Refereed: Yes
Other ID: NLM PMC3398035
PubMed Central ID: PMC3398035
PubMed ID: 22815744
Date Deposited: 05 Oct 2012 19:09
Last Modified: 04 Feb 2019 15:59
URI: http://d-scholarship.pitt.edu/id/eprint/15591

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