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Effect of testosterone and its metabolites upon the level of vasopressin messenger ribonucleic acid in the hypothalamus of the hyperosmotically stimulated male rat.

O'Keefe, JA and Crowley, RS and Hrivnak, P and Kim, NB and Amico, JA (1995) Effect of testosterone and its metabolites upon the level of vasopressin messenger ribonucleic acid in the hypothalamus of the hyperosmotically stimulated male rat. Neuroendocrinology, 61 (4). 405 - 411. ISSN 0028-3835

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Abstract

We previously reported that gonadal steroids modify the expression of arginine vasopressin (AVP) in the hypothalamus of rats administered 2% sodium chloride solution for 5 days. Gonadectomy prevented, and testosterone (T) replacement restored, enhanced AVP mRNA levels in the supraoptic nucleus (SON) of male rats receiving this hyperosmotic challenge. The present study investigated the effects of the androgenic and estrogenic metabolites of T on hypothalamic AVP mRNA levels in response to chronic hyperosmolality. Gonadectomized male rats receiving 2% NaCl for 5 days and treated with T, dihydrotestosterone (DHT), or DHT+estradiol (E2), but not E2 alone or empty implants, had increased AVP mRNA levels compared to gonadectomized animals receiving tap water. Our results support a role for T and DHT-mediated effects upon the enhanced accumulation of AVP mRNA in the SON of male rats receiving a chronic hyperosmotic challenge.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
O'Keefe, JA
Crowley, RS
Hrivnak, P
Kim, NB
Amico, JA
Date: April 1995
Date Type: Publication
Journal or Publication Title: Neuroendocrinology
Volume: 61
Number: 4
Page Range: 405 - 411
DOI or Unique Handle: 10.1159/000126862
Schools and Programs: School of Medicine > Biomedical Informatics
Refereed: Yes
Uncontrolled Keywords: Animals, Arginine Vasopressin, Dihydrotestosterone, Estradiol, Male, Orchiectomy, RNA, Messenger, Rats, Rats, Sprague-Dawley, Supraoptic Nucleus, Testosterone, Water-Electrolyte Balance
ISSN: 0028-3835
Funders: NIDDK NIH HHS (5T32-DK-0752)
MeSH Headings: Animals; Arginine Vasopressin--genetics; Dihydrotestosterone--pharmacology; Estradiol--pharmacology; Male; Orchiectomy; RNA, Messenger--metabolism; Rats; Rats, Sprague-Dawley; Supraoptic Nucleus--metabolism; Testosterone--metabolism; Testosterone--pharmacology; Water-Electrolyte Balance
PubMed ID: 7783853
Date Deposited: 04 Oct 2012 21:36
Last Modified: 27 Feb 2018 18:55
URI: http://d-scholarship.pitt.edu/id/eprint/15611

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