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The Spatial Structure of Stimuli Shapes the Timescale of Correlations in Population Spiking Activity

Litwin-Kumar, A and Chacron, MJ and Doiron, B (2012) The Spatial Structure of Stimuli Shapes the Timescale of Correlations in Population Spiking Activity. PLoS Computational Biology, 8 (9). ISSN 1553-734X

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Throughout the central nervous system, the timescale over which pairs of neural spike trains are correlated is shaped by stimulus structure and behavioral context. Such shaping is thought to underlie important changes in the neural code, but the neural circuitry responsible is largely unknown. In this study, we investigate a stimulus-induced shaping of pairwise spike train correlations in the electrosensory system of weakly electric fish. Simultaneous single unit recordings of principal electrosensory cells show that an increase in the spatial extent of stimuli increases correlations at short (~10 ms) timescales while simultaneously reducing correlations at long (~100 ms) timescales. A spiking network model of the first two stages of electrosensory processing replicates this correlation shaping, under the assumptions that spatially broad stimuli both saturate feedforward afferent input and recruit an open-loop inhibitory feedback pathway. Our model predictions are experimentally verified using both the natural heterogeneity of the electrosensory system and pharmacological blockade of descending feedback projections. For weak stimuli, linear response analysis of the spiking network shows that the reduction of long timescale correlation for spatially broad stimuli is similar to correlation cancellation mechanisms previously suggested to be operative in mammalian cortex. The mechanism for correlation shaping supports population-level filtering of irrelevant distractor stimuli, thereby enhancing the population response to relevant prey and conspecific communication inputs. © 2012 Litwin-Kumar et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Litwin-Kumar, A
Chacron, MJ
Doiron, Bbdoiron@pitt.eduBDOIRON
ContributionContributors NameEmailPitt UsernameORCID
Date: 1 September 2012
Date Type: Publication
Journal or Publication Title: PLoS Computational Biology
Volume: 8
Number: 9
DOI or Unique Handle: 10.1371/journal.pcbi.1002667
Schools and Programs: Dietrich School of Arts and Sciences > Mathematics
Refereed: Yes
ISSN: 1553-734X
Other ID: NLM PMC3441501
PubMed Central ID: PMC3441501
PubMed ID: 23028274
Date Deposited: 19 Oct 2012 21:23
Last Modified: 02 Feb 2019 15:59


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