Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Prehospital dynamic tissue oxygen saturation response predicts in-hospital lifesaving interventions in trauma patients

Guyette, FX and Gomez, H and Suffoletto, B and Quintero, J and Mesquida, J and Kim, HK and Hostler, D and Puyana, JC and Pinsky, MR (2012) Prehospital dynamic tissue oxygen saturation response predicts in-hospital lifesaving interventions in trauma patients. Journal of Trauma and Acute Care Surgery, 72 (4). 930 - 935. ISSN 2163-0755

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


BACKGROUND: Tissue oximetry (StO 2) plus a vascular occlusion test is a noninvasive technology that targets indices of oxygen uptake and delivery. We hypothesize that prehospital tissue oximetric values and vascular occlusion test response can predict the need for in-hospital lifesaving interventions (LSI). METHODS: We conducted a prospective, blinded observational study to evaluate StO 2 slopes to predict the need for LSI. We calculated the DeO 2 slope using Pearson's coefficients of regression (r 2) for the first 25% of descent and the ReO 2 slope using the entire recovery interval. The primary outcome was LSI defined as the need for emergent operation or transfusion in the first 24 hours of hospitalization. We created multivariable logistic regression models using covariates of age, sex, vital signs, lactate, and mental status. RESULTS: We assessed StO 2 in a convenience sample of 150 trauma patients from April to November of 2009. In-hospital mortality was 3% (95% confidence interval [CI], 1.1-7.6); 31% (95% CI, 24-39) were admitted to the intensive care unit, 6% (95% CI, 2.8 -11.1) had an emergent operation, and 10% (95% CI, 5.7-15.9) required transfusion. Decreasing DeO 2 was associated with a higher proportion of patients requiring LSI. In the multivariate model, the association between the need for LSI and DeO 2, Glasgow Coma Scale, and age persists. CONCLUSION: Prehospital DeO 2 is associated with need for LSI in our trauma population. Further study of DeO 2 is warranted to determine whether it can be used as an adjunct triage criterion or an endpoint for resuscitation. Copyright © 2012 by Lippincott Williams & Wilkins.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Guyette, FX
Gomez, H
Suffoletto, B
Quintero, J
Mesquida, J
Kim, HKhyk11@pitt.eduHYK11
Hostler, D
Puyana, JC
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Centers: Other Centers, Institutes, Offices, or Units > McGowan Institute for Regenerative Medicine
Date: 1 April 2012
Date Type: Publication
Journal or Publication Title: Journal of Trauma and Acute Care Surgery
Volume: 72
Number: 4
Page Range: 930 - 935
DOI or Unique Handle: 10.1097/ta.0b013e31823d0677
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 2163-0755
MeSH Headings: Adolescent; Adult; Aged; Aged, 80 and over; Blood Circulation; Emergency Medical Services--statistics & numerical data; Emergency Service, Hospital--statistics & numerical data; Female; Humans; Male; Middle Aged; Oximetry--statistics & numerical data; Predictive Value of Tests; Prospective Studies; Resuscitation--statistics & numerical data; Shock, Traumatic--diagnosis; Shock, Traumatic--etiology; Shock, Traumatic--therapy; Wounds and Injuries--blood; Wounds and Injuries--mortality; Wounds and Injuries--therapy; Young Adult
PubMed ID: 22491607
Date Deposited: 18 Oct 2012 21:13
Last Modified: 22 Jun 2021 14:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item