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Death by parenteral nutrition

Marik, PE and Pinsky, MR (2012) Death by parenteral nutrition. In: Applied Physiology in Intensive Care Medicine 2: Physiological Reviews and Editorials. UNSPECIFIED, 343 - 345. ISBN 9783642282324

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According to the Merriam-Webster Dictionary a poison or toxin is “a substance that through its chemical action usually kills, injures or impairs an organism” [1]. Based on this definition, in the critically ill, total parenteral nutrition (TPN) meets all the criteria of a poison/toxin. Furthermore, TPN exhibits other properties common to many toxins, namely, the presence of a dose response curve (the more you give the greater the toxicity), its toxicity is most evident in those with depressed host defense mechanisms (the critically ill) and an antidote exists (enteral nutrition).


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Item Type: Book Section
Status: Published
CreatorsEmailPitt UsernameORCID
Marik, PE
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Centers: Other Centers, Institutes, Offices, or Units > McGowan Institute for Regenerative Medicine
Date: 1 January 2012
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Page Range: 343 - 345
DOI or Unique Handle: 10.1007/978-3-642-28233-1_37
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISBN: 9783642282324
Title of Book: Applied Physiology in Intensive Care Medicine 2: Physiological Reviews and Editorials
Date Deposited: 12 Dec 2012 20:12
Last Modified: 30 Mar 2021 14:56


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