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Enamel Formation Genes Influence Enamel Microhardness Before and After Cariogenic Challenge

Shimizu, T and Ho, B and Deeley, K and Briseño-Ruiz, J and Faraco, IM and Schupack, BI and Brancher, JA and Pecharki, GD and Küchler, EC and Tannure, PN and Lips, A and Vieira, TCS and Patir, A and Yildirim, M and Poletta, FA and Mereb, JC and Resick, JM and Brandon, CA and Orioli, IM and Castilla, EE and Marazita, ML and Seymen, F and Costa, MC and Granjeiro, JM and Trevilatto, PC and Vieira, AR (2012) Enamel Formation Genes Influence Enamel Microhardness Before and After Cariogenic Challenge. PLoS ONE, 7 (9).

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There is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes may contribute to caries. For the present study, we used DNA samples collected from 1,831 individuals from various population data sets. Single nucleotide polymorphism markers were genotyped in selected genes (ameloblastin, amelogenin, enamelin, tuftelin, and tuftelin interacting protein 11) that influence enamel formation. Allele and genotype frequencies were compared between groups with distinct caries experience. Associations with caries experience can be detected but they are not necessarily replicated in all population groups and the most expressive results was for a marker in AMELX (p = 0.0007). To help interpret these results, we evaluated if enamel microhardness changes under simulated cariogenic challenges are associated with genetic variations in these same genes. After creating an artificial caries lesion, associations could be seen between genetic variation in TUFT1 (p = 0.006) and TUIP11 (p = 0.0006) with enamel microhardness. Our results suggest that the influence of genetic variation of enamel formation genes may influence the dynamic interactions between the enamel surface and the oral cavity. © 2012 Shimizu et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Shimizu, T
Ho, B
Deeley, Kkbd1@pitt.eduKBD1
Briseño-Ruiz, J
Faraco, IM
Schupack, BI
Brancher, JA
Pecharki, GD
Küchler, EC
Tannure, PN
Lips, A
Vieira, TCS
Patir, A
Yildirim, M
Poletta, FA
Mereb, JC
Resick, JM
Brandon, CA
Orioli, IM
Castilla, EE
Marazita, MLmarazita@pitt.eduMARAZITA
Seymen, F
Costa, MC
Granjeiro, JM
Trevilatto, PC
Vieira, ARarv11@pitt.eduARV11
ContributionContributors NameEmailPitt UsernameORCID
Date: 24 September 2012
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 7
Number: 9
DOI or Unique Handle: 10.1371/journal.pone.0045022
Schools and Programs: Graduate School of Public Health > Human Genetics
School of Dental Medicine > Dental Science
Refereed: Yes
Other ID: NLM PMC3454391
PubMed Central ID: PMC3454391
PubMed ID: 23028741
Date Deposited: 19 Oct 2012 21:27
Last Modified: 20 Feb 2020 13:55


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