Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation

Narendran, R and Frankle, WG and Mason, NS and Muldoon, MF and Moghaddam, B (2012) Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation. PLoS ONE, 7 (10).

[img]
Preview
PDF
Published Version
Available under License : See the attached license file.

Download (268kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Studies in rodents indicate that diets deficient in omega-3 polyunsaturated fatty acids (n-3 PUFA) lower dopamine neurotransmission as measured by striatal vesicular monoamine transporter type 2 (VMAT2) density and amphetamine-induced dopamine release. This suggests that dietary supplementation with fish oil might increase VMAT2 availability, enhance dopamine storage and release, and improve dopamine-dependent cognitive functions such as working memory. To investigate this mechanism in humans, positron emission tomography (PET) was used to measure VMAT2 availability pre- and post-supplementation of n-3 PUFA in healthy individuals. Healthy young adult subjects were scanned with PET using [11C]-(+)-α-dihydrotetrabenzine (DTBZ) before and after six months of n-3 PUFA supplementation (Lovaza, 2 g/day containing docosahexaenonic acid, DHA 750 mg/d and eicosapentaenoic acid, EPA 930 mg/d). In addition, subjects underwent a working memory task (n-back) and red blood cell membrane (RBC) fatty acid composition analysis pre- and post-supplementation. RBC analysis showed a significant increase in both DHA and EPA post-supplementation. In contrast, no significant change in [11C]DTBZ binding potential (BPND) in striatum and its subdivisions were observed after supplementation with n-3 PUFA. No correlation was evident between n-3 PUFA induced change in RBC DHA or EPA levels and change in [11C]DTBZ BPNDin striatal subdivisions. However, pre-supplementation RBC DHA levels was predictive of baseline performance (i.e., adjusted hit rate, AHR on 3-back) on the n-back task (y = 0.19+0.07, r2= 0.55, p = 0.009). In addition, subjects AHR performance improved on 3-back post-supplementation (pre 0.65±0.27, post 0.80±0.15, p = 0.04). The correlation between n-back performance, and DHA levels are consistent with reports in which higher DHA levels is related to improved cognitive performance. However, the lack of change in [11C]DBTZ BPNDindicates that striatal VMAT2 regulation is not the mechanism of action by which n-3 PUFA improves cognitive performance. © 2012 Narendran et al.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Narendran, Rran29@pitt.eduRAN29
Frankle, WG
Mason, NS
Muldoon, MFmfm10@pitt.eduMFM10
Moghaddam, Bbita@pitt.eduBITA
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorLe Foll, BernardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 3 October 2012
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 7
Number: 10
DOI or Unique Handle: 10.1371/journal.pone.0046832
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
School of Medicine > Psychiatry
School of Medicine > Radiology
Refereed: Yes
Other ID: NLM PMC3463539
PubMed Central ID: PMC3463539
PubMed ID: 23056476
Date Deposited: 30 Oct 2012 19:12
Last Modified: 13 Oct 2018 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/16056

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item