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Vitamin C Prevents Hypogonadal Bone Loss

Zhu, LL and Cao, J and Sun, M and Yuen, T and Zhou, R and Li, J and Peng, Y and Moonga, SS and Guo, L and Mechanick, JI and Iqbal, J and Peng, L and Blair, HC and Bian, Z and Zaidi, M (2012) Vitamin C Prevents Hypogonadal Bone Loss. PLoS ONE, 7 (10).

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Abstract

Epidemiologic studies correlate low vitamin C intake with bone loss. The genetic deletion of enzymes involved in de novo vitamin C synthesis in mice, likewise, causes severe osteoporosis. However, very few studies have evaluated a protective role of this dietary supplement on the skeleton. Here, we show that the ingestion of vitamin C prevents the low-turnover bone loss following ovariectomy in mice. We show that this prevention in areal bone mineral density and micro-CT parameters results from the stimulation of bone formation, demonstrable in vivo by histomorphometry, bone marker measurements, and quantitative PCR. Notably, the reductions in the bone formation rate, plasma osteocalcin levels, and ex vivo osteoblast gene expression 8 weeks post-ovariectomy are all returned to levels of sham-operated controls. The study establishes vitamin C as a skeletal anabolic agent. © 2012 Zhu et al.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zhu, LL
Cao, J
Sun, M
Yuen, T
Zhou, R
Li, J
Peng, Y
Moonga, SS
Guo, L
Mechanick, JI
Iqbal, J
Peng, L
Blair, HChcblair@pitt.eduHCBLAIR
Bian, Z
Zaidi, M
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorSmith, BrendaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 8 October 2012
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 7
Number: 10
DOI or Unique Handle: 10.1371/journal.pone.0047058
Schools and Programs: School of Medicine > Pathology
Refereed: Yes
Other ID: NLM PMC3466266
PubMed Central ID: PMC3466266
PubMed ID: 23056580
Date Deposited: 30 Oct 2012 18:16
Last Modified: 02 Feb 2019 16:58
URI: http://d-scholarship.pitt.edu/id/eprint/16059

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