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Comparative genomics of the mycobacteriophages: insights into bacteriophage evolution

Hatfull, GF and Cresawn, SG and Hendrix, RW (2008) Comparative genomics of the mycobacteriophages: insights into bacteriophage evolution. Research in Microbiology, 159 (5). 332 - 339. ISSN 0923-2508

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The recognition of the vast numbers of bacteriophages in the biosphere has prompted a renewal of interest in understanding their morphological and genetic diversity, and elucidating the evolutionary mechanisms that give rise to them. We have approached these questions by isolating and characterizing a collection of mycobacteriophages that infect a common bacterial host, Mycobacterium smegmatis. Comparative genomic analysis of 50 mycobacteriophages shows that they are highly diverse, although not uniformly so, that they are pervasively mosaic with a multitude of single gene modules, and that this mosaicism is generated through illegitimate recombination. © 2008 Elsevier Masson SAS. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Hatfull, GFgfh@pitt.eduGFH
Cresawn, SG
Hendrix, RWrhx@pitt.eduRHX
Date: 1 June 2008
Date Type: Publication
Journal or Publication Title: Research in Microbiology
Volume: 159
Number: 5
Page Range: 332 - 339
DOI or Unique Handle: 10.1016/j.resmic.2008.04.008
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0923-2508
MeSH Headings: Amino Acid Sequence; Evolution, Molecular; Genome, Viral; Molecular Sequence Data; Mosaicism; Mycobacteriophages--genetics; Mycobacterium smegmatis--ultrastructure; Mycobacterium smegmatis--virology; Recombination, Genetic
Other ID: NLM NIHMS68436, NLM PMC2632949
PubMed Central ID: PMC2632949
PubMed ID: 18653319
Date Deposited: 15 Nov 2012 20:22
Last Modified: 02 Feb 2019 15:57


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