Hatfull, GF and Cresawn, SG and Hendrix, RW
(2008)
Comparative genomics of the mycobacteriophages: insights into bacteriophage evolution.
Research in Microbiology, 159 (5).
332 - 339.
ISSN 0923-2508
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Abstract
The recognition of the vast numbers of bacteriophages in the biosphere has prompted a renewal of interest in understanding their morphological and genetic diversity, and elucidating the evolutionary mechanisms that give rise to them. We have approached these questions by isolating and characterizing a collection of mycobacteriophages that infect a common bacterial host, Mycobacterium smegmatis. Comparative genomic analysis of 50 mycobacteriophages shows that they are highly diverse, although not uniformly so, that they are pervasively mosaic with a multitude of single gene modules, and that this mosaicism is generated through illegitimate recombination. © 2008 Elsevier Masson SAS. All rights reserved.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
|
Date: |
1 June 2008 |
Date Type: |
Publication |
Journal or Publication Title: |
Research in Microbiology |
Volume: |
159 |
Number: |
5 |
Page Range: |
332 - 339 |
DOI or Unique Handle: |
10.1016/j.resmic.2008.04.008 |
Schools and Programs: |
Dietrich School of Arts and Sciences > Biological Sciences |
Refereed: |
Yes |
ISSN: |
0923-2508 |
MeSH Headings: |
Amino Acid Sequence; Evolution, Molecular; Genome, Viral; Molecular Sequence Data; Mosaicism; Mycobacteriophages--genetics; Mycobacterium smegmatis--ultrastructure; Mycobacterium smegmatis--virology; Recombination, Genetic |
Other ID: |
NLM NIHMS68436, NLM PMC2632949 |
PubMed Central ID: |
PMC2632949 |
PubMed ID: |
18653319 |
Date Deposited: |
15 Nov 2012 20:22 |
Last Modified: |
02 Feb 2019 15:57 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/16239 |
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