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Origins of highly mosaic mycobacteriophage genomes

Pedulla, ML and Ford, ME and Houtz, JM and Karthikeyan, T and Wadsworth, C and Lewis, JA and Jacobs-Sera, D and Falbo, J and Gross, J and Pannunzio, NR and Brucker, W and Kumar, V and Kandasamy, J and Keenan, L and Bardarov, S and Kriakov, J and Lawrence, JG and Jacobs, WR and Hendrix, RW and Hatfull, GF (2003) Origins of highly mosaic mycobacteriophage genomes. Cell, 113 (2). 171 - 182. ISSN 0092-8674

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Abstract

Bacteriophages are the most abundant organisms in the biosphere and play major roles in the ecological balance of microbial life. The genomic sequences of ten newly isolated mycobacteriophages suggest that the bacteriophage population as a whole is amazingly diverse and may represent the largest unexplored reservoir of sequence information in the biosphere. Genomic comparison of these mycobacteriophages contributes to our understanding of the mechanisms of viral evolution and provides compelling evidence for the role of illegitimate recombination in horizontal genetic exchange. The promiscuity of these recombination events results in the inclusion of many unexpected genes including those implicated in mycobacterial latency, the cellular and immune responses to mycobacterial infections, and autoimmune diseases such as human lupus. While the role of phages as vehicles of toxin genes is well established, these observations suggest a much broader involvement of phages in bacterial virulence and the host response to bacterial infections.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pedulla, ML
Ford, ME
Houtz, JM
Karthikeyan, T
Wadsworth, C
Lewis, JA
Jacobs-Sera, Ddjs@pitt.eduDJS0000-0001-7838-3257
Falbo, J
Gross, J
Pannunzio, NR
Brucker, W
Kumar, V
Kandasamy, J
Keenan, L
Bardarov, S
Kriakov, J
Lawrence, JGjlawrenc@pitt.eduJLAWRENC
Jacobs, WR
Hendrix, RWrhx@pitt.eduRHX
Hatfull, GFgfh@pitt.eduGFH
Date: 18 April 2003
Date Type: Publication
Journal or Publication Title: Cell
Volume: 113
Number: 2
Page Range: 171 - 182
DOI or Unique Handle: 10.1016/s0092-8674(03)00233-2
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0092-8674
MeSH Headings: Autoimmune Diseases--genetics; Autoimmune Diseases--immunology; Bacterial Infections--genetics; Bacterial Infections--immunology; Bacterial Toxins--biosynthesis; Bacterial Toxins--genetics; DNA, Viral--genetics; Evolution, Molecular; Gene Expression Regulation, Bacterial--genetics; Gene Expression Regulation, Viral--genetics; Genome, Viral; Host-Parasite Interactions--genetics; Humans; Microscopy, Electron; Molecular Sequence Data; Mosaicism--genetics; Mycobacteriophages--genetics; Mycobacteriophages--metabolism; Mycobacteriophages--ultrastructure; Mycobacterium--genetics; Mycobacterium--pathogenicity; Mycobacterium--virology; Mycobacterium smegmatis--genetics; Mycobacterium smegmatis--metabolism; Mycobacterium smegmatis--virology; Phylogeny; Sequence Homology, Nucleic Acid; Signal Transduction--genetics
PubMed ID: 12705866
Date Deposited: 05 Dec 2012 16:42
Last Modified: 02 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/16456

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